发明授权
- 专利标题： Process for indoles (ring closure of nitro compounds)
- 专利标题（中）： 吲哚的工艺（NITRO化合物的环封闭）
-
申请号： US3682901D申请日： 1969-07-30
-
公开(公告)号： US3682901A公开(公告)日： 1972-08-08
- 发明人: MOHAN ARTHUR GAUDENS , MADISON RICHARD KEITH
- 申请人： ARTHUR GAUDENS MOHAN , RICHARD KEITH MADISON
- 专利权人： Arthur Gaudens Mohan,Richard Keith Madison
- 当前专利权人： Arthur Gaudens Mohan,Richard Keith Madison
- 优先权： US84624669 1969-07-30
- 主分类号： C07D209/08
- IPC分类号： C07D209/08 ; C07D209/12 ; C07D215/04 ; C07D235/02 ; C07D235/08 ; C07D235/18 ; C07D263/56 ; C07D263/57 ; C07D27/56
摘要：
PROCESS FOR PREPARING 2-SUBSTITUTED INDOLES (1) BY REACTING CARBON MONOXIDE AT ELEVATED TEMPERATURE AND SUPERATMOSPHERIC PRESSURE IN THE PRESENCE OF A CO-CATALYST COMPOSIITON, OF WHICH 5% PALLADIUM ON CARBON WITH A LEWIS ACID SUCH AS FERRIC CHLORIDE IS REPRESENTATIVE, WITH AN ONITROBENZYL KETONE (II):
1-(O2N-),2-(R1-CO-CH(-R2)-),R3,R4-BENZENE
TO FORM:
2-R1,3-R2,R3,R4-INDOLE
WHERE R1 IS ALKYL, ARALKYL, ARYL OR STYRYL; R2 IS HYDROGEN ALKYL OR ALRYL, AND R3 AND R4 TYPICALLY ARE HYDROGEN OR ALKYL.
1-(O2N-),2-(R1-CO-CH(-R2)-),R3,R4-BENZENE
TO FORM:
2-R1,3-R2,R3,R4-INDOLE
WHERE R1 IS ALKYL, ARALKYL, ARYL OR STYRYL; R2 IS HYDROGEN ALKYL OR ALRYL, AND R3 AND R4 TYPICALLY ARE HYDROGEN OR ALKYL.
信息查询
