公开(公告)号：US3682901A

公开(公告)日：1972-08-08

申请号：US3682901D

申请日：1969-07-30

申请人： ARTHUR GAUDENS MOHAN ,  RICHARD KEITH MADISON

发明人： MOHAN ARTHUR GAUDENS ,  MADISON RICHARD KEITH

IPC分类号： C07D209/08 ,  C07D209/12 ,  C07D215/04 ,  C07D235/02 ,  C07D235/08 ,  C07D235/18 ,  C07D263/56 ,  C07D263/57 ,  C07D27/56

CPC分类号： C07D215/04 ,  C07D209/08 ,  C07D209/12 ,  C07D235/02 ,  C07D235/08 ,  C07D235/18 ,  C07D263/56 ,  C07D263/57

摘要： PROCESS FOR PREPARING 2-SUBSTITUTED INDOLES (1) BY REACTING CARBON MONOXIDE AT ELEVATED TEMPERATURE AND SUPERATMOSPHERIC PRESSURE IN THE PRESENCE OF A CO-CATALYST COMPOSIITON, OF WHICH 5% PALLADIUM ON CARBON WITH A LEWIS ACID SUCH AS FERRIC CHLORIDE IS REPRESENTATIVE, WITH AN ONITROBENZYL KETONE (II):

1-(O2N-),2-(R1-CO-CH(-R2)-),R3,R4-BENZENE

TO FORM:

2-R1,3-R2,R3,R4-INDOLE

WHERE R1 IS ALKYL, ARALKYL, ARYL OR STYRYL; R2 IS HYDROGEN ALKYL OR ALRYL, AND R3 AND R4 TYPICALLY ARE HYDROGEN OR ALKYL.