Invention Grant
- Patent Title: Process for the preparation of cyclopropane derivatives and compounds produced therein
- Patent Title (中): 制备环丙基衍生物的方法及其生产的化合物
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Application No.: US3723469DApplication Date: 1969-07-11
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Publication No.: US3723469APublication Date: 1973-03-27
- Inventor: MARTEL J
- Applicant: ROUSSEL UCLAF
- Assignee: Roussel Uclaf
- Current Assignee: Roussel Uclaf
- Priority: FR159066 1968-07-12; FR159067 1968-07-12
- Main IPC: A01N53/00
- IPC: A01N53/00 ; A47F5/00 ; A47K1/09 ; C07C51/00 ; C07C61/35 ; C07C61/37 ; C07D307/93 ; C07D5/34
Abstract:
WHEREIN THE CO2H substituent on the carbon 1 and the
Process for the preparation of an internal hemiacylal of racemic or optically active cis 3,3-dimethyl-2-formyl-cyclopropane-1carboxylic acid which are intermediates for the preparation of racemic or optically-active cyclopropane carboxylic acid of the formula
SUBSTITUENT ON THE CARBON 2 ARE IN THE CIS-POSITION RELATIVE TO ONE ANOTHER, R1 represents a hydrogen, an alkyl radical, an aralkyl radical, an aryl radical, an alkenyl radical, an alkynyl radical, a cycloalkyl radical, a cycloalkenyl radical, a heterocyclic radical, these radicals being able to be substituted, specifically by lower alkyl or lower alkoxy, or represents a cyano group, an acyl group, a formyl group, an alkoxy-carbonyl group or a nitro group, and Z represents the R2 residue which has the same meaning as R1 but is identical or different thereto, or the R3 residue, which represents an allyl radical, a benzyl radical, a cyano group, an acyl group, a formyl group, an alkoxycarbonyl group, or a nitro group, or R1 and Z together form a saturated or unsaturated carbon homocycle or heterocycle, whose ring can support substituents such as lower alkyls or lower alkoxys, or functions such as ketonic functions, or together form a polycyclic aromatic residue such as a fluorene residue.
Process for the preparation of an internal hemiacylal of racemic or optically active cis 3,3-dimethyl-2-formyl-cyclopropane-1carboxylic acid which are intermediates for the preparation of racemic or optically-active cyclopropane carboxylic acid of the formula
SUBSTITUENT ON THE CARBON 2 ARE IN THE CIS-POSITION RELATIVE TO ONE ANOTHER, R1 represents a hydrogen, an alkyl radical, an aralkyl radical, an aryl radical, an alkenyl radical, an alkynyl radical, a cycloalkyl radical, a cycloalkenyl radical, a heterocyclic radical, these radicals being able to be substituted, specifically by lower alkyl or lower alkoxy, or represents a cyano group, an acyl group, a formyl group, an alkoxy-carbonyl group or a nitro group, and Z represents the R2 residue which has the same meaning as R1 but is identical or different thereto, or the R3 residue, which represents an allyl radical, a benzyl radical, a cyano group, an acyl group, a formyl group, an alkoxycarbonyl group, or a nitro group, or R1 and Z together form a saturated or unsaturated carbon homocycle or heterocycle, whose ring can support substituents such as lower alkyls or lower alkoxys, or functions such as ketonic functions, or together form a polycyclic aromatic residue such as a fluorene residue.
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