公开(公告)号：US20020072624A1

公开(公告)日：2002-06-13

申请号：US09891433

申请日：2001-06-26

Applicant: Roussel Uclaf

Inventor： Andre Claussner ,  Francois Nique ,  Jean-Georges Teutsch ,  Patrick Van De Velde

IPC: C07J041/00 ,  A61K031/58 ,  A61K031/585 ,  A61K031/56

CPC classification number: C07J31/006 ,  C07J41/0005 ,  C07J41/0016 ,  C07J41/0083 ,  C07J43/003

Abstract: Novel compounds having a formula selected from the group consisting of 1 wherein the substituents are defined as in the specification which are intermediates for the production of vinyl compounds having a remarkable anti-estrogenic and anti-proliferative activity.

Abstract translation: 具有选自下组的式的新型化合物，其中取代基如说明书中所定义，其是制备具有显着抗雌激素和抗增殖活性的乙烯基化合物的中间体。

公开(公告)号：US4027030A

公开(公告)日：1977-05-31

申请号：US65976076

申请日：1976-02-20

Applicant: ROUSSEL UCLAF

Inventor： POITTEVIN ANDRE ,  FOURNEX ROBERT ,  DAGNAUX MICHELE

IPC: C07D277/20 ,  C07D277/56 ,  C07D277/30

CPC classification number: C07D277/56

Abstract: Novel thiazole carboxamides of the formula I wherein R, R1 and R2 are individually selected from the group consisting of hydrogen and alkyl of 1 to 6 carbon atoms and their non-toxic, pharmaceutically acceptable acid addition salts having a marked antilipolytic activity as well as vasodilatatory and hypoglycemic activity and their preparation.

Abstract translation: 式Ia的新型噻唑甲酰胺其中R 1，R 2和R 2分别选自氢和1至6个碳原子的烷基及其无毒的药学上可接受的酸加成盐，其具有显着的抗水解活性， 以及血管舒张和降血糖活性及其制备。

公开(公告)号：US3925399A

公开(公告)日：1975-12-09

申请号：US46518874

申请日：1974-04-29

Applicant: ROUSSEL UCLAF

Inventor： CLEMENCE FRANCOIS ,  LE MARTRET ODILE

IPC: A61K31/425 ,  C07D277/56 ,  C07F5/06

Abstract: The basic aluminum salt of 2-n-propyl-5-thiazolecarboxylic acid having the formula

ITS PREPARATION, HYPOLIPEMIANT COMPOSITIONS CONTAINING THE SAME AND THERAPEUTIC METHODS TO TREAT HYPERLIPEMIA UTILIZING THE HYPOLIPEMIANT COMPOSITIONS.

Abstract translation: 具有式ITS的2-正丙基-5-噻唑甲酸的碱性铝盐，其含有其的高效组合物和治疗使用高效组合物的治疗方法。

公开(公告)号：US3919198A

公开(公告)日：1975-11-11

申请号：US43860274

申请日：1974-02-01

Applicant: ROUSSEL UCLAF

Inventor： WARNANT JULIEN ,  JOLLY JEAN

IPC: C07D303/32 ,  A61K31/585 ,  A61P7/10 ,  A61P9/00 ,  B01J31/00 ,  C07C20060101 ,  C07D20060101 ,  C07J20060101 ,  C07J1/00 ,  C07J9/00 ,  C07J17/00 ,  C07J21/00 ,  C07J31/00 ,  C07J51/00

Abstract: The present invention relates to a dienic derivative of the androstane series having the formula

WHEREIN R is a member selected from the group consisting of hydrogen, alkyl having 1 to 4 carbon atoms and alkali metal, R'' and R'''' are members selected from the group consisting of 1) hydrogen and -COOM, respectively, where M is alkali metal, and 2) taken together, the divalent

group, R2 is a member selected from the group consisting of hydrogen and methyl, with the proviso when R is hydrogen or alkyl having 1 to 4 carbon atoms, R'' and R'''' together are the divalent

group; as well as their process of preparation.

Abstract translation: 本发明涉及具有式WHEREIN R为选自氢，具有1至4个碳原子的烷基和碱金属的成员，R'和R“为选自以下的成员的雄甾烷系的二烯衍生物： 分别由1）氢和-COOM组成的组，其中M是碱金属，和2）合并在一起，二价-C-PARALLEL O基，R2是选自氢和甲基的成员，条件是 当R为氢或具有1至4个碳原子的烷基时，R'和R“一起为二价-C-PARALLEL O基; 以及他们的准备过程。

公开(公告)号：US3910922A

公开(公告)日：1975-10-07

申请号：US83014869

申请日：1969-06-03

Applicant: ROUSSEL UCLAF

Inventor： ALLAIS ANDRE ,  MEIER JEAN

IPC: A61K31/47 ,  C07D215/18 ,  C07D215/22 ,  C07D215/233 ,  C07D215/44 ,  C07D215/56 ,  C07D401/12 ,  C07D405/12 ,  C07D413/12 ,  F24F3/04 ,  C07D215/14

CPC classification number: A61K31/47 ,  C07D215/18 ,  C07D215/233 ,  C07D215/44 ,  C07D215/56 ,  C07D401/12 ,  C07D405/12 ,  C07D413/12

Abstract: 7- OR 8-TRIFLUOROMETHYL-QUINOLINES OF THE FORMULA

WHEREIN N IS 1 OR 2 AND R is selected from the group consisting of saturated and unsaturated heterocyclic having an oxygen atom, a nitrogen atom or both a nitrogen and oxygen atom and their non-toxic, pharmaceutically acceptable acid addition salts having analgesic and anti-inflammatory activity and their preparation.

Abstract translation: 7-或8-三氟甲基喹啉，其中N为1或2，R选自具有氧原子，氮原子或氮原子和氧原子的饱和和不饱和杂环及其无毒性 ，具有镇痛和抗炎活性的药学上可接受的酸加成盐及其制备。

公开(公告)号：US3900468A

公开(公告)日：1975-08-19

申请号：US22652672

申请日：1972-02-15

Applicant: ROUSSEL UCLAF

Inventor： MARTEL JACQUES ,  HEYMES RENE

IPC: C07D501/08 ,  A61K31/545 ,  C07C51/41 ,  C07D501/02 ,  C07D501/22 ,  C07D99/24

CPC classification number: C07C51/412 ,  Y02D70/12 ,  Y02D70/122 ,  C07C59/76

Abstract: Cis, trans and cis-trans mixtures of DL 7-R-amino-desacetoxycephalosporan compounds of the formula

wherein R is selected from the group consisting of hydrogen and trityl and R1 is selected from the group consisting of lower alkyl of 1 to 6 carbon atoms optionally substituted with at least one chlorine and aralkyl of 7 to 15 carbon atoms with the proviso when R is hydrogen, R1 is selected from the group consisting of tert.-butyl,benzyl and ethyl, processes for their preparation and novel intermediates produced therein.

公开(公告)号：US3895039A

公开(公告)日：1975-07-15

申请号：US46447374

申请日：1974-04-26

Applicant: ROUSSEL UCLAF

Inventor： PERRONNET JACQUES ,  GIRAULT PIERRE

IPC: C09D5/14 ,  C07D5/30

CPC classification number: C09D5/14

Abstract: Novel carbamaldoximes of the formula

WHEREIN Y is selected from the group consisting of hydrogen, chlorine and bromine and X is selected from the group consisting of phenyl optionally substituted with at least one member of the group consisting of halogen, cyano, -NO2, alkyl of 1 to 6 carbon atoms and alkoxy of 1 to 6 carbon atoms and nitrofuryl having fungicidal activity.

Abstract translation: 式O的新型卡马尔肟共价XC = NOC-NH-C = CCl 2 I || YCl，其中Y选自氢，氯和溴，X选自任选被至少一个 由卤素，氰基，-NO 2，1至6个碳原子的烷基和1至6个碳原子的烷氧基组成的组的成员和具有杀真菌活性的硝基呋喃。

公开(公告)号：US3887711A

公开(公告)日：1975-06-03

申请号：US48329074

申请日：1974-06-26

Applicant: ROUSSEL UCLAF

Inventor： PERRONNET JACQUES ,  GIRAULT PIERRE

IPC: C09D5/14 ,  A01N9/20

CPC classification number: C09D5/14

Abstract: Novel carbamaldoximes of the formula

WHEREIN Y is selected from the group consisting of hydrogen, chlorine and bromine and X is selected from the group consisting of phenyl optionally substituted with at least one member of the group consisting of halogen, cyano, -NO2, alkyl of 1 to 6 carbon atoms and alkoxy of 1 to 6 carbon atoms and nitrofuryl having fungicidal activity.

Abstract translation: 式VII的新型氨基甲肟酸选自氢，氯和溴，X选自任选被至少一个选自以下的一个基团取代的苯基：卤素，氰基，-NO 2， 1至6个碳原子的烷氧基和1至6个碳原子的烷氧基和具有杀真菌活性的硝基呋喃。

公开(公告)号：US3876637A

公开(公告)日：1975-04-08

申请号：US43076974

申请日：1974-01-04

Applicant: ROUSSEL UCLAF

Inventor： COUSSEDIERE DANIEL ,  NEDELEC LUCIEN ,  TORELLI VESPERTO

IPC: C07J21/00 ,  C07D20060101 ,  C07J1/00 ,  C07J15/00 ,  C07C173/00

Abstract: Wherein R is alkyl of 1 to 3 carbon atoms, R.sub.1 is selected from the group consisting of =0, ketals and
R.sub.2 is selected from the group consisting of hydrogen and acyl of an organic carboxylic acid of 1 to 12 carbon atoms and X is selected from the group consisting of hydrogen and hydroxy which are valuable intermediates for the preparation of steroids such as adrenosterone.

Racemates and optically active isomers of novel .DELTA..sup.9 gonene-11-ones of the formula

公开(公告)号：US3872092A

公开(公告)日：1975-03-18

申请号：US43356974

申请日：1974-01-15

Applicant: ROUSSEL UCLAF

Inventor： TEUTSCH JEAN GEORGES

IPC: C07J1/00 ,  A61K31/565 ,  A61P5/00 ,  C07J7/00 ,  C07J21/00 ,  C07J71/00 ,  C07J75/00 ,  C07C173/00

CPC classification number: C07J71/001 ,  C07J7/0045 ,  C07J21/006

Abstract: Novel Delta 9,11-gonadiene-5 Alpha -ols of the formula

WHEREIN R is alkyl of 1 to 4 carbon atoms, K is a blocked ketone in the form of a ketal, thioketal or methyloxime, preferably a ketal, and X is the rest of a pentagonal ring optionally substituted and their preparation which are useful intermediates for the preparation of Delta 4,9,11-gonatrienes.

Abstract translation: 新型的具有1-4个碳原子的烷基的DELTA 9,11-雄二烯-5α-醇，K是酮缩酮，硫代缩酮或甲基肟，优选缩酮形式的封端酮，X是 剩余的五角环任选取代，它们的制备是制备DELTA 4,9,11-高三烯的有用的中间体。