发明授权
- 专利标题： Process for the production of 6-aminopenicillanic acid
- 专利标题（中）： 生产6-氨基苯甲酸的方法
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申请号： US3737375D申请日： 1970-11-25
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公开(公告)号： US3737375A公开(公告)日： 1973-06-05
- 发明人: BRANDL E , KLEIBER W , KNAUSEDER F
- 申请人： BIOCHEMIE GMBH
- 专利权人： Biochemie Gmbh
- 当前专利权人： Biochemie Gmbh
- 优先权： AT1114869 1969-11-28
- 主分类号： C12P37/06
- IPC分类号： C12P37/06 ; A61K31/43 ; C07C20060101 ; C07D20060101 ; C07D499/10 ; C07D499/42 ; C12R1/01 ; C12D9/00
摘要：
THE INVENTION CONCERNS A NOVEL CLEAVAGE PROCESS FOR THE PRODUCTION OF 6-AMINOPENICILLANIC ACID, WHICH COMPRISES CONTACTING A PENICILLIN OF THE FORMULA:
6-(R-CO-NH-),2-(HOOC-),3,3-DI(CH3-)PENAM
WHEREIN R IS PHENOXYMETHYL, P-CRESOXYMETHYL OR NBUTOXYMETHYL, OR AN ALKALI METAL SALT OF SAID PENICILLIN, WITH PENICILLIN AMIDASE PRODUCED BY CULTURING UNDER AEROBIC CONDITIONS BOVISTA PLUMBEA (NNRL 3501) OR A MUTANT OR VARIANT THEREOF IN AN AQUEOUS MEDIUM CONTAINING ASSIMILABLE SOURCES OF CARBON AND NITROGEN.
6-(R-CO-NH-),2-(HOOC-),3,3-DI(CH3-)PENAM
WHEREIN R IS PHENOXYMETHYL, P-CRESOXYMETHYL OR NBUTOXYMETHYL, OR AN ALKALI METAL SALT OF SAID PENICILLIN, WITH PENICILLIN AMIDASE PRODUCED BY CULTURING UNDER AEROBIC CONDITIONS BOVISTA PLUMBEA (NNRL 3501) OR A MUTANT OR VARIANT THEREOF IN AN AQUEOUS MEDIUM CONTAINING ASSIMILABLE SOURCES OF CARBON AND NITROGEN.
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