发明授权
- 专利标题： Dibenzooxazepines and dibenzothiazepines
- 专利标题（中）： 二苯并咪唑和二苯并噻吩
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申请号： US3780059D申请日： 1971-08-17
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公开(公告)号： US3780059A公开(公告)日： 1973-12-18
- 发明人: YALE H , BERNSTEIN J
- 申请人： SQUIBB & SONS INC
- 专利权人： E R Squibb and Sons LLC
- 当前专利权人： E R Squibb and Sons LLC
- 优先权： US1797270 1970-03-09; US17256971 1971-08-17
- 主分类号： C07D267/18
- IPC分类号： C07D267/18 ; C07D267/20 ; C07D267/22 ; C07D269/00 ; C07D281/12 ; C07D283/00 ; C07D403/06 ; C07D27/52
摘要：
THERAPEUTICALLY ACTIVE COMPOUNDS UTILIZABLE AS ATARACTIC AGENTS AND AS SEDATIVES AND HYPOTENSIVE AGENTS HAVING THE FORMULA
R1-NH-C(=NH)-N(-R2)-(CH2)R-N
(CH(-R))N-X-(CH(-R))P-(R4-1,2-PHENYLENE)-(CH(-R))M-)
WHEREIN R, R1 AND R2 ARE HYDROGEN, LOWER ALKYL, PHENYL OR PHENYL-LOWER ALKYL; R3 AND R4 ARE HYDROGEN, HALOGEN, LOWER ALKYL, TRIFLUOROMETHYL, OR LOWER ALKOXY; X IS OXYGEN OR SULFUR; R IS 2 TO 5; M IS 0 OR 1; N AND P ARE EACH 0, 1 OR 2; PROVIDED THAT THE SUM OF M+N+P BEING FROM 1 TO 3, AND THAT WHEN M EQUALS 1 AND N AND P ARE EACH 0, X IS SULFUR.
R1-NH-C(=NH)-N(-R2)-(CH2)R-N
(CH(-R))N-X-(CH(-R))P-(R4-1,2-PHENYLENE)-(CH(-R))M-)
WHEREIN R, R1 AND R2 ARE HYDROGEN, LOWER ALKYL, PHENYL OR PHENYL-LOWER ALKYL; R3 AND R4 ARE HYDROGEN, HALOGEN, LOWER ALKYL, TRIFLUOROMETHYL, OR LOWER ALKOXY; X IS OXYGEN OR SULFUR; R IS 2 TO 5; M IS 0 OR 1; N AND P ARE EACH 0, 1 OR 2; PROVIDED THAT THE SUM OF M+N+P BEING FROM 1 TO 3, AND THAT WHEN M EQUALS 1 AND N AND P ARE EACH 0, X IS SULFUR.
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