发明授权
- 专利标题： Dichloro-substituted estradiene
- 专利标题（中）： DICHLORO取代的ESTRADIENE
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申请号： US85348069申请日： 1969-08-27
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公开(公告)号： US3812166A公开(公告)日： 1974-05-21
- 发明人: WIECHERT R , STEINBECK H
- 申请人： SCHERING AG
- 专利权人： Bayer Schering Pharma AG
- 当前专利权人： Bayer Schering Pharma AG
- 优先权： DE1793422 1968-09-13
- 主分类号： A61K
- IPC分类号： A61K20060101 ; A61K31/565 ; A61K31/58 ; C07C20060101 ; C07J1/00 ; C07J17/00 ; C07C169/22
摘要：
A RACEMIC OR OPTICALLY ACTIVE, 4,6-DICHLORO-4,6-ESTRADIENE OF THE FORMULA
4,6-DI(CL-),17-(R-O-),17-(CH*C-),18-CH3-ESTRA-4,6-DIEN-
3-ONE
WHEREIN R IS HYDROGEN, ALKYL, TETRADROPYRANYL OR AN ACID RESIDUE. TO FORM THE COMPOUNDS, THE 4-UNSUBSTITUTED 6-CHLOROESTRADIENE IS SUBJECTED TO THE ACTION OF AN AGENT FURNISHING POSITIVE AND NEGATIVE CHLORINE, THEREBY FORMING THE 6,6,7-TRICHLORO-SUBSTITUTED COMPOUND, FOLLOWED BY TREATMENT OF THE LATTER COMPOUND WITH A BASE. THE COMPOUNDS HAVE A VERY HIGH PROGESTERONE ACTIVITY.
4,6-DI(CL-),17-(R-O-),17-(CH*C-),18-CH3-ESTRA-4,6-DIEN-
3-ONE
WHEREIN R IS HYDROGEN, ALKYL, TETRADROPYRANYL OR AN ACID RESIDUE. TO FORM THE COMPOUNDS, THE 4-UNSUBSTITUTED 6-CHLOROESTRADIENE IS SUBJECTED TO THE ACTION OF AN AGENT FURNISHING POSITIVE AND NEGATIVE CHLORINE, THEREBY FORMING THE 6,6,7-TRICHLORO-SUBSTITUTED COMPOUND, FOLLOWED BY TREATMENT OF THE LATTER COMPOUND WITH A BASE. THE COMPOUNDS HAVE A VERY HIGH PROGESTERONE ACTIVITY.