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20 条记录 (耗时 0.011 秒)

    Benzopyran derivatives
    1.
    发明授权
    Benzopyran derivatives 失效
    BENZOPYRAN衍生物

    公开(公告)号：US3849447A

    公开(公告)日：1974-11-19

    申请号：US26121672

    申请日：1972-06-09

    申请人： SCHERING AG

    发明人： EDER U ,  WIECHERT R

    IPC分类号： C07D311/94 ,  G04F3/06 ,  H01H43/10 ,  C07D7/20

    CPC分类号： H01H43/10 ,  C07C2603/16 ,  G04F3/06

    摘要： 1. A BENZOPYRAN OF THE FORMULA

    2,3-(-CH2-CH2-C(-)(-R1)-C(-X)(-H(Y))-(CH2)N-B-A-),5-R2,

    5-(R3-O-)-5,6-DIHYDROPYRAN WHERE C(-) AND A ARE JOINED

    WHEREIN R1, R2 AND R3 EACH ARE LOWER ALKYL; N IS THE INTEGER 1 OR 2; A--B IS CH--CH2 OR C=CH; X IS OH, ALKOXY OF 1--10 CARBON ATOMS, ALKANOYLOXY OF 1-10 CARBON ATOMS OR BENZYLOXY AND Y IS H.

    Novel pregnanoic acid derivatives
    3.
    发明授权
    Novel pregnanoic acid derivatives 失效

    公开(公告)号：US3824260A

    公开(公告)日：1974-07-16

    申请号：US28471072

    申请日：1972-08-30

    申请人： SCHERING AG

    发明人： LAURENT H ,  HOFMEISTER H ,  GERHARDS E ,  WIECHERT R ,  PREZEWOWSKY K ,  KOLB K ,  MENGEL K

    IPC分类号： C07D20060101 ,  C07C169/36

    摘要： PREGNANOIC ACID DERIVATIVES OF THE FORMULA

    2-R1,3-(R2O-CO-CO-),3A-(H3C-),5-Z,5A-Y,6-(H3C-),6,7-(-A-B-

    CO-CH=),8-X-PERHYDRO-BENZ(E)INDENE

    WHEREIN X IS HYDROGEN,HALOGEN,ORMETHYL; Y IS HYDROGEN ORHALOGEN; Z IS HYDROXY OR HALOGEN HAVING AN ATOMIC WEIGHT NO GREATER THAN Y; R1 IS HYDROGEN OR METHYL; R2 IS HYDROGEN, ALKALI METAL OR SUBSTITUTED OR UNSUBSTITUTED HYDROCARBON OF 1-8 CARBON ATOMS WHICH IS UNSUBSTITUTED OR SUBSTITUTED BY HYDROXY, HALO, ALKOXY, CARBOXY, CARBALKOXY, AMINO, ALKYLAMINO, DIALKYLAMINO, NITRO OR SULFATO, WHEREIN ALKYL IN EACH INSTANCE CONTAINS 1-4 CARBON ATOMS; AND --A--B--IS--CH=CH--,--CCI=CH-- OR, WHEN AT LEAST ONE OF X, Y AND R1 IS OTHER THAN HYDROGEN, --CH2--CH2; PROCESS PRONOUNCED TOPICAL ANTI-INFLAMMATORY ACTIVITY.

    Dichloro-substituted estradiene
    4.
    发明授权
    Dichloro-substituted estradiene 失效
    DICHLORO取代的ESTRADIENE

    公开(公告)号：US3812166A

    公开(公告)日：1974-05-21

    申请号：US85348069

    申请日：1969-08-27

    申请人： SCHERING AG

    发明人： WIECHERT R ,  STEINBECK H

    IPC分类号： A61K20060101 ,  A61K31/565 ,  A61K31/58 ,  C07C20060101 ,  C07J1/00 ,  C07J17/00 ,  C07C169/22

    CPC分类号： C07J75/00

    摘要： A RACEMIC OR OPTICALLY ACTIVE, 4,6-DICHLORO-4,6-ESTRADIENE OF THE FORMULA

    4,6-DI(CL-),17-(R-O-),17-(CH*C-),18-CH3-ESTRA-4,6-DIEN-

    3-ONE

    WHEREIN R IS HYDROGEN, ALKYL, TETRADROPYRANYL OR AN ACID RESIDUE. TO FORM THE COMPOUNDS, THE 4-UNSUBSTITUTED 6-CHLOROESTRADIENE IS SUBJECTED TO THE ACTION OF AN AGENT FURNISHING POSITIVE AND NEGATIVE CHLORINE, THEREBY FORMING THE 6,6,7-TRICHLORO-SUBSTITUTED COMPOUND, FOLLOWED BY TREATMENT OF THE LATTER COMPOUND WITH A BASE. THE COMPOUNDS HAVE A VERY HIGH PROGESTERONE ACTIVITY.

    17-chloro steroids
    6.
    发明授权
    17-chloro steroids 失效
    17-CHLORO STEROIDS

    公开(公告)号：US3723484A

    公开(公告)日：1973-03-27

    申请号：US3723484D

    申请日：1971-09-15

    申请人： SCHERING AG

    发明人： LAURENT H ,  WIECHERT R ,  KOLB K

    IPC分类号： A61K20060101 ,  A61K31/57 ,  C07C20060101 ,  C07J5/00 ,  C07C169/30

    CPC分类号： C07J5/00 ,  Y10S514/825 ,  Y10S514/861 ,  Y10S514/863

    摘要： 17-Chloro anti-inflammatory steroids of the formula

    WHEREIN X is H or Cl; Y is F or Cl; Z is OH, F or, when Y is Cl, Cl; and R is a free or esterified OH group, are produced by simultaneously reacting, in the presence of a sulfone, the corresponding 17-hydrogen compound or the corresponding Delta 9(11)-17-hydrogen compound with hydrogen fluoride and with an Nchloroacylamide or N-chloroacylimide.

    摘要翻译： 17-氯类抗炎类固醇，式为WHEREIN X为H或Cl; Y为F或Cl; Z是OH，F或当Y是Cl时，Cl; 并且R是游离的或酯化的OH基团，通过在砜的存在下，将相应的17-氢化合物或相应的DELTA 9（11）-17-氢化合物与氟化氢和N- 氯酰酰胺或N-氯酰酰亚胺。

    Novel pregnanoic acid derivatives
    7.
    发明授权
    Novel pregnanoic acid derivatives 失效
    新型孕激素衍生物

    公开(公告)号：US3833563A

    公开(公告)日：1974-09-03

    申请号：US29452772

    申请日：1972-10-03

    申请人： SCHERING AG

    发明人： PREZEWOWSKY K ,  HOFMEISTER H ,  LAURENT H ,  WIECHERT R ,  KOLB K ,  GERHARDS E ,  MENGEL K

    IPC分类号： A61K31/573 ,  C07J5/00 ,  C07C173/00

    CPC分类号： A61K31/573 ,  C07J5/00

    摘要： CH=),8-X-PERHYDROBENZ(E)INDENE

    PREGNANOIC ACID DERIVATIVES OF THE FORMULA

    2-R1,3-(R3O-CO-CH(-OR2)-),3A,6-DI(H3C-),5-Z,6,7-(-B-A-CO-
    WHEREIN THE GROUP OR2 IS IN THE AF- OR BF-POSITION; X IS HYDROGEN, HALOGEN OR METHYL; Y IS HYDROGEN OR HALOGEN; Z IS HYDROXY OR HALOGEN HAVING AN ATOMIC WEIGHT NO GREATER THAN Y; R1 IS HYDROGEN OR METHYL; R2 IS HYDROGEN OR ACYL AND R3 IS HYDROGEN, ALKALI METAL OR SATURATED OR UNSATURATED UNSUBSTITUTED OR SUBSTITUTED HYDROCARBON OF 1-18 CARBON ATOMS, OR COLLECTIVELY R2 AND R3 ARE DIALKYLMETHYLENE OR CYCLOALKYLIDENE; AND AT LEAST ONE OF X, Y AND R1 ARE OTHER THAN HYDROGEN; AND -A-B- IS

    -CH2-CH2-, -CH=CH- OR -CCL=CH;

    POSSESS PRONOUNCED TOPICAL ANTI-INFLAMMATORY ACTIVITY AS WELL AS BEING INTERMEDIATES FOR THE PRODUCTION OF THE CORRESPONDING 20-KETO STEROIDS.

    Process for the preparation of pregnane derivatives
    9.
    发明授权
    Process for the preparation of pregnane derivatives 失效
    制备PREGNANE衍生物的方法

    公开(公告)号：US3741997A

    公开(公告)日：1973-06-26

    申请号：US3741997D

    申请日：1971-05-04

    申请人： SCHERING AG

    发明人： BERNDT H ,  WIECHERT R

    IPC分类号： C07J7/00 ,  C07C20060101 ,  C07J5/00 ,  C07J31/00 ,  C07J51/00 ,  C07J61/00 ,  C07C167/00 ,  C07C169/00

    CPC分类号： C07J75/00

    摘要： 17 Beta -Hydroxy-17 Alpha -ethynyl steroids are converted to 17-ethers and 17-esters of 17 Alpha -hydroxy-20-keto-pregnane steroids by forming a 17-sulfite ester of the 17 Beta -hydroxy group with thionyl chloride in the presence of base and then reacting the sulfite ester with an alcohol or carboxylic acid in the presence of an Hg salt.

    摘要翻译： 17β-羟基-17α-乙炔基类固醇通过将17β-羟基的17-亚硫酸酯与亚硫酰氯反应，转化成17α-羟基-20-酮 - 孕烷类固醇的17-醚和17-酯 碱的存在，然后在Hg ++存在下使亚硫酸酯与醇或羧酸反应。