A cleaning method and system for meat smokehouses and similar meat processing facilities including a plurality of atomizing spray nozzles positioned within the smokehouse and the duct work therein. While air and steam are circulated within the smokehouse, a cleanser solution is introduced into the facility through the atomizing spray nozzles. The atomized cleansing solution provides a saturated atmosphere of cleanser which is carried to all surfaces of the smokehouse by the circulating air. After completion of the wash operation, pure water and/or a weakly acid aqueous solution is introduced into the smokehouse through the nozzle system to effect rinsing of the smokehouse.