Invention Grant
- Patent Title: Process for production of AT-125
- Patent Title (中): 生产AT-125的工艺
-
Application No.: US50363374Application Date: 1974-09-06
-
Publication No.: US3878047APublication Date: 1975-04-15
- Inventor: HANKA LADISLAV J , MARTIN DAVID G
- Applicant: UPJOHN CO
- Assignee: Upjohn Co
- Current Assignee: Upjohn Co
- Priority: US50363374 1974-09-06; US32900173 1973-02-02
- Main IPC: C07D261/04
- IPC: C07D261/04 ; C07G11/00 ; C12D9/00
Abstract:
Antibiotic AT-125, producible by culturing Streptomyces sviceus in an aqueous nutrient medium has the following structure:
The absolute configuration of AT-125 was determined to be L-( Alpha S,5S)- Alpha -amino-3-chloro-2-isoxazoline-5-acetic acid. It is an amphoteric compound and can exist in different ionic forms according to the pH of the environment. At low pH, AT-125 exists in the acid-addition salt form, at a higher pH in a zwitterion form, and at a still higher pH in a metal salt form. AT-125 inhibits the growth of Bacillus subtilis, Saccharomyces pastorianus, Penicillium oxalicum, Candida albicans, Saccharomyces cerevisiae and Escherichia coli, and can be used to inhibit such microorganisms in various environments.
The absolute configuration of AT-125 was determined to be L-( Alpha S,5S)- Alpha -amino-3-chloro-2-isoxazoline-5-acetic acid. It is an amphoteric compound and can exist in different ionic forms according to the pH of the environment. At low pH, AT-125 exists in the acid-addition salt form, at a higher pH in a zwitterion form, and at a still higher pH in a metal salt form. AT-125 inhibits the growth of Bacillus subtilis, Saccharomyces pastorianus, Penicillium oxalicum, Candida albicans, Saccharomyces cerevisiae and Escherichia coli, and can be used to inhibit such microorganisms in various environments.
Information query
