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    Derivatives of 1,4-dihydro-3h-2,3-benzoxazine
    1.
    发明授权
    Derivatives of 1,4-dihydro-3h-2,3-benzoxazine 失效
    1,4-二氢-3H-2,3-苯并恶唑衍生物

    公开(公告)号：US3625967A

    公开(公告)日：1971-12-07

    申请号：US3625967D

    申请日：1967-11-29

    Applicant: UPJOHN CO

    Inventor： MARTIN DAVID G

    IPC: C07D265/02 ,  C07D273/00 ,  C07D87/12

    CPC classification number: C07D273/00 ,  C07D265/02

    Abstract: 1,6-Dihydro-4-phenyl-2,5,3-benzodioxazocine (1), 1,4-dihydro-3H2,3-benzoxazine-3-carboxamide (1''a), N-alkyl-1,4-dihydro-3H-2,3benzoxazine-3-carboxamides (1''b), 1,4-dihydro-3H-2,3-benzoxazine3-carboxamidine (1''c) and its acid addition salts, process for the preparation thereof and novel intermediates prepared by said processes. Compounds 1, 1''a, and 1''b principally exhibit antilipemic activity. Compound 1''c is useful for preparing mothproofing agents and inhibitors that can be used in the acid pickling of steel.

    1,4-dihydro-3h-2,3-benzoxazine derivatives
    2.
    发明授权
    1,4-dihydro-3h-2,3-benzoxazine derivatives 失效
    1,4-二氢-3H-2,3-苯并恶唑衍生物

    公开(公告)号：US3553214A

    公开(公告)日：1971-01-05

    申请号：US3553214D

    申请日：1968-06-05

    Applicant: UPJOHN CO

    Inventor： MARTIN DAVID G

    IPC: C07D265/02 ,  C07D87/12

    CPC classification number: C07D265/02

    Abstract: 1,4-DIHYDRO-3H-2,3-BENZOXAZINE IS REACTED WITH HALOPHENYL CHLOROFORMATE TO FORM HALOPHENYL ESTERS OF 1,4DIHYDRO-3H-2,3-BENZOXAZINE-3-CARBOXYLIC ACID. THE 1,4DIHYDRO-3H-2,3-BENZOXAZINE-3-CARBOXYLIC ACID HALOPHENYL ESTERS HAVE UTILITY AS ANTIFUNGAL AND ANTILIPEMIC AGENTS.

    Process for production of AT-125
    7.
    发明授权
    Process for production of AT-125 失效
    生产AT-125的工艺

    公开(公告)号：US3878047A

    公开(公告)日：1975-04-15

    申请号：US50363374

    申请日：1974-09-06

    Applicant: UPJOHN CO

    Inventor： HANKA LADISLAV J ,  MARTIN DAVID G

    IPC: C07D261/04 ,  C07G11/00 ,  C12D9/00

    CPC classification number: C07D261/04 ,  C07G11/00 ,  Y10S435/803 ,  Y10S435/886

    Abstract: Antibiotic AT-125, producible by culturing Streptomyces sviceus in an aqueous nutrient medium has the following structure:
    The absolute configuration of AT-125 was determined to be L-( Alpha S,5S)- Alpha -amino-3-chloro-2-isoxazoline-5-acetic acid. It is an amphoteric compound and can exist in different ionic forms according to the pH of the environment. At low pH, AT-125 exists in the acid-addition salt form, at a higher pH in a zwitterion form, and at a still higher pH in a metal salt form. AT-125 inhibits the growth of Bacillus subtilis, Saccharomyces pastorianus, Penicillium oxalicum, Candida albicans, Saccharomyces cerevisiae and Escherichia coli, and can be used to inhibit such microorganisms in various environments.

    Abstract translation: 通过在水性营养培养基中培养链霉菌可生产的抗生素AT-125具有以下结构：

    Antiobotic alpha - methyldethiobiotin alpha methylbiotin and their esters
    8.
    发明授权
    Antiobotic alpha - methyldethiobiotin alpha methylbiotin and their esters 失效
    抗生素ALPHA - 甲基二氢生物素ALPHA甲基生物素及其衍生物

    公开(公告)号：US3658837A

    公开(公告)日：1972-04-25

    申请号：US3658837D

    申请日：1969-05-19

    Applicant: UPJOHN CO

    Inventor： HANKA LADISLAV J ,  MARTIN DAVID G

    IPC: C07D233/32 ,  C07D495/04 ,  C07D49/30

    CPC classification number: C07D495/04 ,  C07D233/32 ,  Y10S435/886 ,  Y10S514/924

    Abstract: ANTIBIOTICS A-METHYLDETHIOBIOTIN, A-METHYLBIOTIN, AND THEIR ESTERS, A-METHYLDETHIOBIOTIN AND ITS ESTERS HAVE THE FOLLOWING FORMULA:

    4-CH3,5-(R-OOC-CH(-CH3)-(CH2)4-)IMIDAZOLIDIN-2-ONE

    WHEREIN R IS HYDROGEN OR T-(BUTYL, PHTHALIMIDOMETHYL AND PHENACYL. A-METHYLBIOTIN AND ITS ESTERS HAVE THE FOLLOWING FORMULA:

    4-(R-OOC-C(-CH3)-(CH2)3-)HEXAHYDROTHIENO(3,4-D)-

    IMIDAZOL-2-ONE

    WHEREIN R IS AS DEFINED ABOVE. A-METHYLDETHIOBIOTIN, WHERE R IS HYDROGEN IN FORMULA I, AND A-METHYLBIOTIN, WHERE R IS HYDROGEN IN FORMULA II, ARE PRODUCED IN A LYDIMYCIN FERMENTATION. THESE COMPOUNDS ARE ACTIVE AGAINST MYCOBACTERIUM AVIUM AND CAN BE USED TO CONTROL THIS MICROORGNISM WHICH IS A KNOWN PRODUCER OF GENERALIZED TUBERCULOSIS IN BIRDS AND RABBITS.

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