发明授权
US3897415A 5-Substituted 1,2,4-triazole-3-carboxamido nucleosides and analogs thereof
失效
5-取代的1,2,4-三唑-3-甲酰氨基核苷及其类似物
- 专利标题： 5-Substituted 1,2,4-triazole-3-carboxamido nucleosides and analogs thereof
- 专利标题（中）： 5-取代的1,2,4-三唑-3-甲酰氨基核苷及其类似物
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申请号： US29292972申请日： 1972-09-28
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公开(公告)号： US3897415A公开(公告)日： 1975-07-29
- 发明人: ROBINS ROLAND K , WITKOWSKI JOSEPH T
- 申请人： ICN PHARMACEUTICALS
- 专利权人： Icn Pharmaceuticals
- 当前专利权人： Icn Pharmaceuticals
- 优先权： US29292972 1972-09-28; US14901771 1971-06-01; US24025272 1972-03-31
- 主分类号： C07H19/04
- IPC分类号： C07H19/04 ; C07D51/50
摘要：
Disubstituted 1,2,4-triazole nucleosides, e.g., those of structure
WHEREIN R is hydrogen or acyl and X and Y are differently selected from the group consisting of halogen, carboxamide and carboxylic acid ester groups are prepared by a method comprising fusion of an appropriately substituted 1,2,4-triazole with a tetra-O-acyl blocked ribofuranose. Disubstituted 1,2,4-triazole nucleosides prepared according to the invention have variously exhibited antimicrobial and antiviral activity in vitro, while others are useful in the preparation of such compounds.
WHEREIN R is hydrogen or acyl and X and Y are differently selected from the group consisting of halogen, carboxamide and carboxylic acid ester groups are prepared by a method comprising fusion of an appropriately substituted 1,2,4-triazole with a tetra-O-acyl blocked ribofuranose. Disubstituted 1,2,4-triazole nucleosides prepared according to the invention have variously exhibited antimicrobial and antiviral activity in vitro, while others are useful in the preparation of such compounds.
公开/授权文献
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