发明授权
US3933834A Unsymmetrical esters of N-substituted 1,4-dihydropyridine
3,5-dicarboxylic acid
失效
N-取代的1,4-二氢吡啶3,5-二羧酸的不对称酯
- 专利标题： Unsymmetrical esters of N-substituted 1,4-dihydropyridine 3,5-dicarboxylic acid
- 专利标题（中）： N-取代的1,4-二氢吡啶3,5-二羧酸的不对称酯
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申请号： US496972申请日： 1974-08-13
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公开(公告)号： US3933834A公开(公告)日： 1976-01-20
- 发明人: Horst Meyer , Friedrich Bossert , Wulf Vater , Kurt Stoepel
- 申请人： Horst Meyer , Friedrich Bossert , Wulf Vater , Kurt Stoepel
- 申请人地址： DT
- 专利权人： Bayer Aktiengesellschaft
- 当前专利权人： Bayer Aktiengesellschaft
- 当前专利权人地址： DT
- 优先权： DT2210672 19720603
- 主分类号： C07D405/04
- IPC分类号： C07D405/04 ; C07D213/55
摘要：
Unsymmetrical esters of N-substituted 4-substituted-1,4-dihydropyridine 3,5-dicarboxylic acid substituted in the 4-position by pyridyl, thienyl, furyl and pyrryl and optionally substituted in the 2- and 6-positions by lower alkyl. The products can be prepared (A) through condensation of an ylidene-.beta.-ketocarboxylic acid ester, with a .beta.-ketocarboxylic acid ester and an amine or salt thereof, or with an enamino carboxylic acid ester or (B) through condensation of an aldehyde, an enamino carboxylic acid ester and a .beta.-ketocarboxylic acid ester. The said products have utility as cardiovascular agents.
公开/授权文献
- US5736074A Manufacture of coated spheres 公开/授权日：1998-04-07
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