发明授权
- 专利标题： Penicillins substituted with heterocyclic groups
- 专利标题（中）： 青霉素被杂环基取代
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申请号： US491693申请日： 1974-07-25
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公开(公告)号： US3951955A公开(公告)日： 1976-04-20
- 发明人: Hisao Tobiki , Kozo Shimago , Shigeru Okano , Toshiaki Komatsu , Toyozo Katsura , Yasushi Taira , Yasuko Eda
- 申请人： Hisao Tobiki , Kozo Shimago , Shigeru Okano , Toshiaki Komatsu , Toyozo Katsura , Yasushi Taira , Yasuko Eda
- 申请人地址： JA
- 专利权人： Sumitomo Chemical Company, Limited
- 当前专利权人： Sumitomo Chemical Company, Limited
- 当前专利权人地址： JA
- 优先权： JA45-124374 19701229; JA45-124377 19701229
- 主分类号： C07D499/00
- IPC分类号： C07D499/00 ; C07D499/64 ; C07D499/44
摘要：
A penicillin of the formula: ##SPC1##Wherein A is a substituted or unsubstituted condensed aromatic carbocyclic or heterocyclic ring, R is hydrogen or lower alkyl, X is oxygen or sulfur, Y is hydrogen, lower alkyl, lower alkanoyl or lower alkoxycarbonyl and Z is phenyl or thienyl which can be produced by reacting 6-aminopenicillanic acid or its ester with a carboxylic acid of the formula: ##SPC2##Wherein A, R, X, Y and Z are each as defined above or its reactive derivative. The said penicillin and its non-toxic salts have a broad antimicrobial spectrum against various gram-positive and gram-negative bacteria, and they exhibit characteristically a strong antimicrobial activity against Pseudomonas.