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公开(公告)号:US3951955A
公开(公告)日:1976-04-20
申请号:US491693
申请日:1974-07-25
申请人: Hisao Tobiki , Kozo Shimago , Shigeru Okano , Toshiaki Komatsu , Toyozo Katsura , Yasushi Taira , Yasuko Eda
发明人: Hisao Tobiki , Kozo Shimago , Shigeru Okano , Toshiaki Komatsu , Toyozo Katsura , Yasushi Taira , Yasuko Eda
IPC分类号: C07D499/00 , C07D499/64 , C07D499/44
CPC分类号: C07D499/00
摘要: A penicillin of the formula: ##SPC1##Wherein A is a substituted or unsubstituted condensed aromatic carbocyclic or heterocyclic ring, R is hydrogen or lower alkyl, X is oxygen or sulfur, Y is hydrogen, lower alkyl, lower alkanoyl or lower alkoxycarbonyl and Z is phenyl or thienyl which can be produced by reacting 6-aminopenicillanic acid or its ester with a carboxylic acid of the formula: ##SPC2##Wherein A, R, X, Y and Z are each as defined above or its reactive derivative. The said penicillin and its non-toxic salts have a broad antimicrobial spectrum against various gram-positive and gram-negative bacteria, and they exhibit characteristically a strong antimicrobial activity against Pseudomonas.
摘要翻译: 青霉素的配方: