发明授权
US3979397A Pharmaceutically effective novel 3,4-dihydro-1,2- and 1,3-thiozolo [4,3a] i
s
失效
药学有效的新型3,4-二氢-1,2-和1,3-噻唑并{8,43a {9 {0异喹啉及其制备方法
- 专利标题： Pharmaceutically effective novel 3,4-dihydro-1,2- and 1,3-thiozolo [4,3a] i s
- 专利标题（中）： 药学有效的新型3,4-二氢-1,2-和1,3-噻唑并{8,43a {9 {0异喹啉及其制备方法
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申请号： US473918申请日： 1974-05-28
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公开(公告)号： US3979397A公开(公告)日： 1976-09-07
- 发明人: Kalman Harsanyi , Kalman Takacs , Pal Kiss , Laszlo Szekeres , Gyula Papp , Eva Benedek
- 申请人： Kalman Harsanyi , Kalman Takacs , Pal Kiss , Laszlo Szekeres , Gyula Papp , Eva Benedek
- 申请人地址： HU Budapest
- 专利权人： Chinoin Pharmaceutical and Chemical Works Ltd.
- 当前专利权人： Chinoin Pharmaceutical and Chemical Works Ltd.
- 当前专利权人地址： HU Budapest
- 优先权： HUCI1381 19730530
- 主分类号： A61K31/47
- IPC分类号： A61K31/47 ; A61P9/00 ; A61P9/04 ; A61P9/08 ; A61P9/10 ; A61P11/16 ; C07D217/08 ; C07D277/60 ; C07D513/04
摘要：
The invention relates to new thiazoloisoquinolines of the general formula (I), or salts thereof, ##SPC1##WhereinA stands for a group of the formula ##EQU1## R.sup.1 stands for hydrogen, hydroxy, alkoxy or aralkoxy, R.sup.2 stands for hydrogen, hydroxy, alkoxy or aralkoxy,R.sup.3 stands for hydrogen, alkyl, aryl, nitro, carboxy or a carboxy derivative, andY stands for oxygen, sulfur, or a group of the formula =N--R.sup.4, wherein R.sup.4 stands for hydrogen, alkyl, aryl, acyl, alkylsulfonyl or arylsulfonyl.These new compounds can be used in practice as heart medicines or respiratory analeptics.The new compounds according to the invention can be prepared as follows: an isoquinoline of the general formula (II) or a salt thereof ##SPC2##WhereinR.sup.5 stands for hydrogen, hydroxy, alkoxy or aralkoxy,R.sup.6 stands for hydrogen, hydroxy, alkoxy or aralkoxy,R.sup.7 stands for hydrogen, alkyl, aryl, carboxy or a carboxy derivative, andX stands for hydrogen, halogen or mercapto,Is reacted with a reactive carbonic acid derivative, provided that at least one of the reactants contains a sulfur atom, and/or an isoquinoline of the general formula (III) ##SPC3##wherein R.sup.5, R.sup.6 and R.sup.7 each have the same meanings as defined above, and Y' stands for oxygen, sulfur or a group of the formula =N--R.sup. 8, wherein R.sup.8 represents hydrogen, alkyl, aryl, acyl, arylsulfonyl or alkylsulfonyl, is oxidized, and/or substituents A', R.sup.5, R.sup.6 and R.sup.7 of the obtained thiazoloisoquinoline of the general formula (IA) ##SPC4##wherein A' stands for a group of the formula ##EQU2## and R.sup.5, R.sup.6, R.sup.7 and Y' each have the same meanings as defined above, are converted into those required in the end-products.
公开/授权文献
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