The invention relates to a method of making one-piece wheels for large locarrying vehicles. Starting from a blank in the form of a cylindrical disc, the minor flange of the rim and the wheel disc are formed by hot stamping, while the major flange of the rim is obtained by press-forming from a tube section. The two parts are assembled by welding. The production cycle terminates in a few finishing operations by machining. These wheels, which may be made in particular of lightweight aluminum-based alloys, are particularly suitable for large load-carrying vehicles fitted with tubeless tires.