发明授权
US4056633A D-homo-20-ketopregnanes and method for inducing anesthesia or narcosis
失效
D-均聚-20-酮戊二酸和诱导麻醉或麻醉的方法
- 专利标题： D-homo-20-ketopregnanes and method for inducing anesthesia or narcosis
- 专利标题（中）： D-均聚-20-酮戊二酸和诱导麻醉或麻醉的方法
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申请号： US641602申请日： 1975-12-17
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公开(公告)号： US4056633A公开(公告)日： 1977-11-01
- 发明人: Ulrich Kerb , Rudolf Wiechert , Helmut Wachtel , Otto Engelfried , Klaus Kieslich
- 申请人： Ulrich Kerb , Rudolf Wiechert , Helmut Wachtel , Otto Engelfried , Klaus Kieslich
- 申请人地址： DT Berlin and Bergkamen
- 专利权人： Schering Aktiengesellschaft
- 当前专利权人： Schering Aktiengesellschaft
- 当前专利权人地址： DT Berlin and Bergkamen
- 优先权： DT2461312 19741223; DT2506688 19750214
- 主分类号： A61K31/12
- IPC分类号： A61K31/12 ; A61K31/56 ; C07J63/00 ; C07J71/00 ; C01B33/24
摘要：
D-homo-20-ketopregnanes of the formula ##STR1## wherein R.sub.1 is hydrogen, fluorine, chlorine, bromine, alkyl, alkoxy, or azido;R.sub.2 is oxygen, ##STR2## and R.sub.7 is hydrogen, lower alkyl, or acyl of up to 5 carbon atoms; R.sub.3 is hydrogen or methylR.sub.4 is oxygen, two hydrogens, ##STR3## R.sub.5 is hydrogen, hydroxy, alkoxy, azido, mercapto, thiocyano, cyano, dialkylamino, morpholino, thiomorpholino, or piperazino;R.sub.6 is methyl or ethyl;The hydrogen atom in the 5-position is of the .alpha.- or .beta.-configuration;And acid addition salts thereof, possess narcotic-anesthetic activity.
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