发明授权
US4070470A Platelet aggregation inhibiting carbostyrils, their compositions and
method of use
失效
血小板聚集抑制喹诺酮类,其组成和使用方法
- 专利标题: Platelet aggregation inhibiting carbostyrils, their compositions and method of use
- 专利标题(中): 血小板聚集抑制喹诺酮类,其组成和使用方法
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申请号: US588475申请日: 1975-06-19
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公开(公告)号: US4070470A公开(公告)日: 1978-01-24
- 发明人: Kazuyukip Nakagawa , Minoru Uchida , Kimiaki Oka
- 申请人: Kazuyukip Nakagawa , Minoru Uchida , Kimiaki Oka
- 申请人地址: JA Tokyo
- 专利权人: Otsuka Pharmaceutical Co., Ltd.
- 当前专利权人: Otsuka Pharmaceutical Co., Ltd.
- 当前专利权人地址: JA Tokyo
- 优先权: JA50-58872 19750516; JA50-58874 19750516; JA50-66729 19750602; JA49-72472 19740624; JA49-72473 19740624; JA49-77660 19740705; JA49-77661 19740705; JA49-94376 19740816; JA50-53026 19750430; JA50-53027 19750430; JA50-53028 19750430; JA50-58127 19750515; JA50-58128 19750515; JA50-58129 19750515; JA50-58134 19750515; JA50-58135 19750515
- 主分类号: C07D209/34
- IPC分类号: C07D209/34 ; C07D215/22 ; C07D215/227 ; C07D215/26 ; A61K31/47
摘要:
Novel benzcycloamide derivatives represented by the general formula, ##STR1## wherein R.sub.1 is hydrogen, C.sub.1-4 alkyl, C.sub.2-4 alkenyl or aralkyl; B is --CH.sub.2 --, --CH.sub.2 --CH.sub.2 -- or --CH.dbd.CH--; A is ##STR2## (wherein R.sub.2 and R.sub.3 may be the same or different and are respectively hydrogen or C.sub.1-4 alkyl) or --CH.dbd.CH--; R.sub.4 is --OR.sub.5 (wherein R.sub.5 is hydrogen, C.sub.1-8 alkyl, cycloalkyl or aralkyl) or ##STR3## (wherein R.sub.6 and R.sub.7 may be the same or different and are respectively hydrogen, C.sub.1-4 alkyl or aralkyl or may form together with the nitrogen atom a 5- or 6-membered heterocyclic group which may further contain a nitrogen, oxygen or sulfur atom); and m and n each are zero or a positive integer and m + n is no more than 11.The benzcycloamide derivatives represented by the above-mentioned general formula (I) have excellent effects of inhibiting platelet aggregation and are useful as preventives for thrombosis and embolism.
公开/授权文献
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