公开(公告)号：US4313947A

公开(公告)日：1982-02-02

申请号：US58467

申请日：1979-07-18

申请人： Kamuyuki Nakagawa ,  Minoru Uchida ,  Kimiaki Oka

发明人： Kamuyuki Nakagawa ,  Minoru Uchida ,  Kimiaki Oka

IPC分类号： C07D209/34 ,  C07D215/22 ,  C07D215/227 ,  C07D215/26 ,  C07D209/04

CPC分类号： C07D215/227 ,  C07D209/34 ,  C07D215/26

摘要： 2-oxyindole derivatives represented by the following general formula: ##STR1## where R.sub.1 is selected from the group consisting of hydrogen, C.sub.1-4 alkyl, C.sub.2-4 alkenyl, benzyl and phenethyl; A is --CH.dbd.CH-- or ##STR2## wherein R.sub.2 or R.sub.3 may be the same or different and are selected from the group consisting of hydrogen and C.sub.1-4 alkyl; R.sub.6 and R.sub.7 may be the same or different and are selected from the group consisting of hydrogen, C.sub.1-4 alkyl, benzyl, phenethyl and together with the nitrogen atom, a heterocyclic group selected from the group consisting of a piperidino, morpholino, piperazino or thiazolino group; and m and n each are zero or a positive integer with m+n being no more than 11. The 2-oxyindole derivatives have excellent effects on the inhibition of platelet aggregation.

摘要翻译： 由下列通式表示的2-氧吲哚衍生物：其中R 1选自氢，C 1-4烷基，C 2-4链烯基，苄基和苯乙基; A是-CH = CH-或其中R 2或R 3可以相同或不同，并且选自氢和C 1-4烷基; R 6和R 7可以相同或不同，并且选自氢，C 1-4烷基，苄基，苯乙基和氮原子，选自哌啶子基，吗啉代，哌嗪基或 噻唑啉基; m和n各自为零或m + n不大于11的正整数。2-氧吲哚衍生物对抑制血小板聚集具有优异的效果。

公开(公告)号：US4070470A

公开(公告)日：1978-01-24

申请号：US588475

申请日：1975-06-19

申请人： Kazuyukip Nakagawa ,  Minoru Uchida ,  Kimiaki Oka

发明人： Kazuyukip Nakagawa ,  Minoru Uchida ,  Kimiaki Oka

IPC分类号： C07D209/34 ,  C07D215/22 ,  C07D215/227 ,  C07D215/26 ,  A61K31/47

CPC分类号： C07D215/227 ,  C07D209/34 ,  C07D215/26 ,  Y10S514/822

摘要： Novel benzcycloamide derivatives represented by the general formula, ##STR1## wherein R.sub.1 is hydrogen, C.sub.1-4 alkyl, C.sub.2-4 alkenyl or aralkyl; B is --CH.sub.2 --, --CH.sub.2 --CH.sub.2 -- or --CH.dbd.CH--; A is ##STR2## (wherein R.sub.2 and R.sub.3 may be the same or different and are respectively hydrogen or C.sub.1-4 alkyl) or --CH.dbd.CH--; R.sub.4 is --OR.sub.5 (wherein R.sub.5 is hydrogen, C.sub.1-8 alkyl, cycloalkyl or aralkyl) or ##STR3## (wherein R.sub.6 and R.sub.7 may be the same or different and are respectively hydrogen, C.sub.1-4 alkyl or aralkyl or may form together with the nitrogen atom a 5- or 6-membered heterocyclic group which may further contain a nitrogen, oxygen or sulfur atom); and m and n each are zero or a positive integer and m + n is no more than 11.The benzcycloamide derivatives represented by the above-mentioned general formula (I) have excellent effects of inhibiting platelet aggregation and are useful as preventives for thrombosis and embolism.

摘要翻译： 由通式表示的新型苯并环己胺衍生物，其中R 1是氢，C 1-4烷基，C 2-4链烯基或芳烷基; B是-CH 2 - ， - CH 2 -CH 2 - 或-CH = CH-; A是（其中R 2和R 3可以相同或不同，分别为氢或C 1-4烷基）或-CH = CH-; R4是-OR5（其中R5是氢，C1-8烷基，环烷基或芳烷基）或者其中R6和R7可以相同或不同，分别是氢，C1-4烷基或芳烷基，或者可以与 氮原子可以进一步含有氮，氧或硫原子的5-或6-元杂环基）; m和n分别为零或正整数，m + n不大于11。

公开(公告)号：US4216220A

公开(公告)日：1980-08-05

申请号：US806926

申请日：1977-06-15

申请人： Kazuyuki Nakagawa ,  Minoru Uchida ,  Kimiaki Oka

发明人： Kazuyuki Nakagawa ,  Minoru Uchida ,  Kimiaki Oka

IPC分类号： C07D209/34 ,  C07D215/22 ,  C07D215/227 ,  C07D215/26 ,  C07D209/04

CPC分类号： C07D215/227 ,  C07D209/34 ,  C07D215/26 ,  Y10S514/822

摘要： 2-Oxyindole derivatives represented by the following general formula: ##STR1## where R.sub.1 is selected from the group consisting of hydrogen, C.sub.1-4 alkyl, C.sub.2-4 alkenyl, benzyl and phenethyl; A is --CH.dbd.CH-- or ##STR2## wherein R.sub.2 or R.sub.3 may be the same or different and are selected from the group consisting of hydrogen and C.sub.1-4 alkyl; R.sub.4 is --OR.sub.5, wherein R.sub.5 is selected from the group consisting of hydrogen, C.sub.1-8 alkyl, cyclohexyl, benzyl and phenethyl, or ##STR3## wherein R.sub.6 and R.sub.7 may be the same or different and are selected from the group consisting of hydrogen, C.sub.1-4 alkyl, benzyl, phenethyl and together with the nitrogen atom, a heterocyclic group selected from the group consisting of a piperidino, morpholino, piperazino or thiazolino group; and m and n each are zero or a positive integer with m+n being no more than 11. The 2-oxyindole derivatives have excellent effects on the inhibition of platelet aggregation.

摘要翻译： 由下列通式表示的2-氧吲哚衍生物：其中R 1选自氢，C 1-4烷基，C 2-4链烯基，苄基和苯乙基; A是-CH = CH-或其中R 2或R 3可以相同或不同，并且选自氢和C 1-4烷基; R 4是-OR 5，其中R 5选自氢，C 1-8烷基，环己基，苄基和苯乙基，或其中R 6和R 7可以相同或不同，并且选自氢 ，C 1-4烷基，苄基，苯乙基和氮原子一起选自哌啶子基，吗啉代，哌嗪基或噻唑基的杂环基; m和n各自为零或m + n不大于11的正整数。2-氧吲哚衍生物对抑制血小板聚集具有优异的效果。