发明授权
US4094884A 4.alpha.-Hydroxy-6-oxo-2.beta.- arylmethoxy-methyl-3.alpha.-tetrahydropyranacetic acid .gamma.-lactones 失效
4 {60-羟基-6-氧代-2 {62-芳基甲氧基 - 甲基-3 {60-四氢吡喃乙酸{65-内酯

  • 专利标题: 4.alpha.-Hydroxy-6-oxo-2.beta.- arylmethoxy-methyl-3.alpha.-tetrahydropyranacetic acid .gamma.-lactones
  • 专利标题(中): 4 {60-羟基-6-氧代-2 {62-芳基甲氧基 - 甲基-3 {60-四氢吡喃乙酸{65-内酯
  • 申请号: US784173
    申请日: 1977-04-04
  • 公开(公告)号: US4094884A
    公开(公告)日: 1978-06-13
  • 发明人: Robert C. Kelly
  • 申请人: Robert C. Kelly
  • 申请人地址: MI Kalamazoo
  • 专利权人: The Upjohn Company
  • 当前专利权人: The Upjohn Company
  • 当前专利权人地址: MI Kalamazoo
  • 主分类号: C07D309/22
  • IPC分类号: C07D309/22 C07D493/02 C07D493/04
4.alpha.-Hydroxy-6-oxo-2.beta.-
arylmethoxy-methyl-3.alpha.-tetrahydropyranacetic acid .gamma.-lactones
摘要:
The present specification provides novel intermediates and novel processes for the synthesis of Thromboxane B.sub.2 (11a-homo-11a-oxa-PGF.sub.2.alpha.), its 15-epimer, and various carboxyl derivatives thereof. In particular, there are disclosed various bicyclic tetrahydrofuran-containing lactones useful in the above processes, and corresponding acyclic lactones.
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