发明授权
- 专利标题： Process for the preparation of pregnane derivatives
- 专利标题（中）： 孕烷衍生物的制备方法
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申请号： US802329申请日： 1977-06-01
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公开(公告)号： US4102908A公开(公告)日： 1978-07-25
- 发明人: Helmut Hofmeister , Klaus Annen , Henry Laurent , Rudolf Wiechert
- 申请人： Helmut Hofmeister , Klaus Annen , Henry Laurent , Rudolf Wiechert
- 申请人地址： DE Berlin and Bergkamen
- 专利权人： Schering Aktiengesellschaft
- 当前专利权人： Schering Aktiengesellschaft
- 当前专利权人地址： DE Berlin and Bergkamen
- 优先权： DE2625306 19760602
- 主分类号： C07J7/00
- IPC分类号： C07J7/00 ; C07J41/00 ; C07J5/00
摘要：
A process for the preparation of pregnane derivatives of the formula ##STR1## wherein R.sub.1 is methyl or ethyl and R.sub.2 is methyl, ethyl, formyl, or acetyl, comprises reacting a nitrate ester of the formula ##STR2## wherein R.sub.1 is as above, in the presence of a catalytic amount of a mercury salt of a lower carboxylic acid with formic acid or acetic acid in a dipolar aprotic or basic solvent or with methanol or ethanol in an aprotonic, especially water-miscible, solvent in the presence of a mineral acid.
公开/授权文献
- US6011029A Inhibitors of farnesyl protein transferase 公开/授权日：2000-01-04