发明授权
US4113871A Hypoglycemically and hypolipidemically active derivatives of
phenyl-alkane-carboxylic acids
失效
苯基 - 羧酸 - 羧酸的高分子和低分子活性衍生物
- 专利标题: Hypoglycemically and hypolipidemically active derivatives of phenyl-alkane-carboxylic acids
- 专利标题(中): 苯基 - 羧酸 - 羧酸的高分子和低分子活性衍生物
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申请号: US674993申请日: 1976-04-08
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公开(公告)号: US4113871A公开(公告)日: 1978-09-12
- 发明人: Kurt Stach, deceased , Elmar Bosies , Ruth Heerdt , Hans-Frieder Kuhnle , Felix Helmut Schmidt
- 申请人: Kurt Stach, deceased , Elmar Bosies , Ruth Heerdt , Hans-Frieder Kuhnle , Felix Helmut Schmidt
- 申请人地址: DE Mannheim
- 专利权人: Boehringer Mannheim GmbH
- 当前专利权人: Boehringer Mannheim GmbH
- 当前专利权人地址: DE Mannheim
- 优先权: DE2517229 19750418; DE2604560 19760206
- 主分类号: C07D209/42
- IPC分类号: C07D209/42 ; A61K31/165 ; C07C67/00 ; C07C231/00 ; C07C231/02 ; C07C231/12 ; C07C233/51 ; C07C233/54 ; C07C233/55 ; C07C233/81 ; C07C233/87 ; C07C235/20 ; C07C235/24 ; C07C235/34 ; C07C235/36 ; C07C235/38 ; C07C235/52 ; C07C235/56 ; C07C237/20 ; C07C237/36 ; C07C237/40 ; C07C313/00 ; C07C319/20 ; C07C323/60 ; C07D213/82 ; C07D215/48 ; C07D241/24 ; C07D261/18 ; C07D263/58 ; C07D307/79 ; C07D311/66 ; C07D333/38 ; A61K31/42 ; A61K31/34
摘要:
Phenyl-alkane-carboxylic acids of the formula ##STR1## wherein A is an aryl, aralkyl or arylvinyl radical optionally substituted by hydroxy, halogen, trifluoromethyl, alkyl, alkylthio, alkoxy, alkenyloxy, alkoxyalkoxy, alkyl-substituted amino, aryloxy or alkoxy-substituted aryloxy, or is an aryloxyalkyl or arylthioalkyl radical, or a heterocyclic ring system optionally substituted by halogen, alkyl or alkoxy,Y is a valency bond or an unbranched or branched lower alkylene radical containing up to 3 carbon atoms,X is a straight or branched, saturated or unsaturated divalent aliphatic hydrocarbon radical containing 2 to 8 carbon atoms, there being at least 2 carbon atoms between the benzene ring and the carboxyl group, andR is a hydrogen atom or a lower alkyl radical, as well as physiologically compatible salts, esters and amides thereof, exhibit hypoglycaemic and hypolipidaemic activity.
公开/授权文献
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