公开(公告)号：US20240360098A1

公开(公告)日：2024-10-31

申请号：US18591732

申请日：2024-02-29

申请人： Bayer Aktiengesellschaft

发明人： David Bernier ,  Stéphane Brunet ,  Jérémy Dufour ,  Thomas Knobloch ,  Lionel Nicolas ,  Tomoki Tsuchiya

IPC分类号： C07D333/38 ,  A01N43/10 ,  A01N43/76 ,  A01N55/00 ,  A01P1/00 ,  A01P13/00 ,  A61P31/04 ,  A61P33/00 ,  C07D409/12 ,  C07D413/04 ,  C07F7/08

CPC分类号： C07D333/38 ,  A01N43/10 ,  A01N43/76 ,  A01N55/00 ,  A01P1/00 ,  A01P13/00 ,  A61P31/04 ,  A61P33/00 ,  C07D409/12 ,  C07D413/04 ,  C07F7/0812 ,  C07F7/083

摘要： The present disclosure relates to substituted thiophene carboxamides and analogues thereof that may be used for protecting plants from bacterial diseases, in particular from bacterial diseases caused by bacteria belonging to the genus Xanthomonas.

公开(公告)号：US12110281B2

公开(公告)日：2024-10-08

申请号：US17261561

申请日：2019-07-17

申请人： HEXAPHARMATEC CO., LTD.

发明人： Shin Han ,  Jae-Hyoung Lee

IPC分类号： C07D333/38 ,  A61P1/16 ,  C07D409/12

CPC分类号： C07D333/38 ,  A61P1/16 ,  C07D409/12

摘要： Provided is a novel catechol derivative or pharmaceutically acceptable salt thereof having an alkyl moiety substituted with alkylamino and/or a N-alkyl-substituted thiophene-(thio)carboxamide moiety, a process for the preparation thereof, and a pharmaceutical composition including the same.

公开(公告)号：US20240317733A1

公开(公告)日：2024-09-26

申请号：US18449326

申请日：2023-08-14

申请人： Takeda Pharmaceutical Company Limited

发明人： Shigemitsu MATSUMOTO ,  Yasushi HATTORI ,  Masashi TOYOFUKU ,  Shinji MORIMOTO ,  Masaki DAINI ,  Takuto KOJIMA ,  Tomohiro KAKU ,  Mitsuhiro ITO

IPC分类号： C07D417/14 ,  C07D213/82 ,  C07D231/12 ,  C07D231/14 ,  C07D277/56 ,  C07D285/08 ,  C07D285/135 ,  C07D307/79 ,  C07D307/81 ,  C07D333/38 ,  C07D333/40 ,  C07D407/12 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12

CPC分类号： C07D417/14 ,  C07D213/82 ,  C07D231/12 ,  C07D231/14 ,  C07D277/56 ,  C07D285/08 ,  C07D285/135 ,  C07D307/79 ,  C07D307/81 ,  C07D333/38 ,  C07D333/40 ,  C07D407/12 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12

摘要： The present invention provides a compound having a lysine-specific demethylase-1 inhibitory action, and useful as a medicament such as a prophylactic or therapeutic agent for schizophrenia, developmental disorders, particularly diseases having intellectual disability (e.g., autistic spectrum disorders, Rett syndrome, Down's syndrome, Kabuki syndrome, fragile X syndrome, Kleefstra syndrome, neurofibromatosis type 1, Noonan syndrome, tuberous sclerosis), neurodegenerative diseases (e.g., Alzheimer's disease, Parkinson's disease, spinocerebellar degeneration (e.g., dentatorubral pallidoluysian atrophy) and Huntington's disease), epilepsy (e.g., Dravet syndrome) or drug dependence, and the like. A compound represented by the formula




wherein each symbol is as defined in the present specification, or a salt thereof.

公开(公告)号：US20240316047A1

公开(公告)日：2024-09-26

申请号：US18620110

申请日：2024-03-28

申请人： ACCENT THERAPEUTICS, INC.

发明人： Matthew H. Daniels ,  Kenneth W. Duncan ,  Brian Andrew Sparling ,  Andrew Stewart Tasker ,  Gavin Whitlock

IPC分类号： A61K31/506 ,  A61K31/18 ,  A61K31/277 ,  A61K31/341 ,  A61K31/381 ,  A61K31/40 ,  A61K31/415 ,  A61K31/4164 ,  A61K31/437 ,  A61K31/4418 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/496 ,  A61K31/497 ,  A61K31/4985 ,  A61K31/5377 ,  A61K31/675 ,  A61P35/00 ,  C07C311/08 ,  C07D207/34 ,  C07D213/56 ,  C07D231/12 ,  C07D231/14 ,  C07D233/90 ,  C07D307/68 ,  C07D333/38 ,  C07D333/70 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D409/04 ,  C07D409/14 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04 ,  C07F9/6558

CPC分类号： A61K31/506 ,  A61K31/18 ,  A61K31/277 ,  A61K31/341 ,  A61K31/381 ,  A61K31/40 ,  A61K31/415 ,  A61K31/4164 ,  A61K31/437 ,  A61K31/4418 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/496 ,  A61K31/497 ,  A61K31/4985 ,  A61K31/5377 ,  A61K31/675 ,  A61P35/00 ,  C07C311/08 ,  C07D207/34 ,  C07D213/56 ,  C07D231/12 ,  C07D231/14 ,  C07D233/90 ,  C07D307/68 ,  C07D333/38 ,  C07D333/70 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D409/04 ,  C07D409/14 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04 ,  C07F9/65583

摘要： Provided are compounds of the Formula (IVB):




or pharmaceutically acceptable salts thereof, which are useful for the inhibition of DHX9 and in the treatment of a variety of DHX9 mediated conditions or diseases, such as cancer.

公开(公告)号：US20240277657A1

公开(公告)日：2024-08-22

申请号：US18566730

申请日：2022-06-03

申请人： KYOTO PHARMACEUTICAL UNIVERSITY

发明人： Susumu Nakata ,  Naoto Kojima

IPC分类号： A61K31/381 ,  A61K31/415 ,  A61P35/00 ,  C07D231/14 ,  C07D333/38

CPC分类号： A61K31/381 ,  A61K31/415 ,  A61P35/00 ,  C07D231/14 ,  C07D333/38

摘要： The present invention aims to provide a novel AMP-activated protein kinase activator.
The present invention relates to a compound represented by the formula (I):




wherein each symbol is as described in the specification, or a salt thereof, or a hydrate thereof. In addition, the present invention relates to an AMP-activated protein kinase activator containing the aforementioned compound, and a medicament containing the aforementioned compound for the prophylaxis and/or treatment of cancer.

公开(公告)号：US20240254098A1

公开(公告)日：2024-08-01

申请号：US18560078

申请日：2022-05-10

申请人： ALTIBIO, INC.

发明人： Charles M. COOK ,  Marc Patrick REICHENBERGER ,  Shripad BHAGWAT

IPC分类号： C07D333/38 ,  A61K31/381

CPC分类号： C07D333/38 ,  A61K31/381

摘要： Provided herein are compounds, thioester prodrugs thereof, compositions, and methods for the treatment of diseases and disorders associated with renal anomalies.

公开(公告)号：US11952359B2

公开(公告)日：2024-04-09

申请号：US17810214

申请日：2022-06-30

申请人： Bayer Aktiengesellschaft

发明人： David Bernier ,  Stéphane Brunet ,  Jérémy Dufour ,  Thomas Knobloch ,  Lionel Nicolas ,  Tomoki Tsuchiya

IPC分类号： C07D333/40 ,  A01N43/10 ,  A01N43/76 ,  A01N55/00 ,  A01P1/00 ,  A01P13/00 ,  A61P31/04 ,  A61P33/00 ,  C07D333/38 ,  C07D409/12 ,  C07D413/04 ,  C07F7/08

CPC分类号： C07D333/38 ,  A01N43/10 ,  A01N43/76 ,  A01N55/00 ,  A01P1/00 ,  A01P13/00 ,  A61P31/04 ,  A61P33/00 ,  C07D409/12 ,  C07D413/04 ,  C07F7/0812 ,  C07F7/083

摘要： The present disclosure relates to substituted thiophene carboxamides and analogues thereof of formula (I) that may be used for protecting plants from bacterial diseases, in particular from bacterial diseases caused by bacteria belonging to the genus Xanthomonas.

公开(公告)号：US20230365582A1

公开(公告)日：2023-11-16

申请号：US18042352

申请日：2021-08-20

申请人： KANAPH THERAPEUTICS INC. ,  KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

发明人： Young Sook SHIN ,  Sang Kyun LIM ,  Yeri LEE ,  Donggeon KIM ,  Soo Bong HAN ,  Chang Soo YUN ,  Hyun Jin KIM ,  Joo Youn LEE ,  Hyuk LEE ,  Sikwang SEONG

IPC分类号： C07D495/04 ,  C07D333/24 ,  C07D333/38 ,  C07D409/10 ,  C07D409/06

CPC分类号： C07D495/04 ,  C07D333/24 ,  C07D333/38 ,  C07D409/10 ,  C07D409/06

摘要： The present application relates to a novel compound having inhibitory activity on prostaglandin E2 receptor and uses thereof, and provides a compound represented by formula I, a solvate, stereoisomer or pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the same, and a method of using the same.

公开(公告)号：US20230212184A1

公开(公告)日：2023-07-06

申请号：US18121886

申请日：2023-03-15

申请人： Takeda Pharmaceutical Company Limited

发明人： Koichiro FUKUOKA ,  Kazuhiro MIWA

IPC分类号： C07D495/04 ,  C07D409/12 ,  C07D333/38

CPC分类号： C07D495/04 ,  C07D409/12 ,  C07D333/38

摘要： The present invention provides a production method of a thienopyrimidine derivative or a salt thereof which has a gonadotropin releasing hormone (GnRH) antagonistic action with high quality in high yield. The present invention provides a method of producing a thienopyrimidine derivative, which comprises reacting 6-(4-aminophenyl)-1-(2,6-difluorobenzyl)-5-dimethylaminomethyl-3-(6-methoxypyridazin-3-yl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione or salt thereof, 1,1′-carbonyldiimidazole or a salt thereof and methoxyamine or a salt thereof, and the like.

公开(公告)号：US11655238B2

公开(公告)日：2023-05-23

申请号：US17295227

申请日：2019-11-20

申请人： SHANGHAITECH UNIVERSITY

发明人： Zihe Rao ,  Jun Li ,  Bing Zhang ,  Haitao Yang

IPC分类号： C07D403/04 ,  C07D207/327 ,  C07D231/14 ,  C07D233/90 ,  C07D249/10 ,  C07D333/38 ,  C07D401/04 ,  C07D405/04

CPC分类号： C07D403/04 ,  C07D207/327 ,  C07D231/14 ,  C07D233/90 ,  C07D249/10 ,  C07D333/38 ,  C07D401/04 ,  C07D405/04

摘要： The present disclosure relates generally to inhibitors of mycobacterial membrane protein MmpL3, compositions comprising the inhibitors, and methods of preparation and use thereof.