发明授权
US4167570A 2-Methyl-6-alkyl-11-aminoalkyl-6,11-dihydro-5H-pyrido(2,3-B)(1,5)benzodia
zepin-5-ones and salts thereof
失效
2-甲基-6-烷基-11-氨基烷基-6,11-二氢-5H-吡啶并(2,3-B)(1,5)苯并二氮杂-5-酮及其盐
- 专利标题: 2-Methyl-6-alkyl-11-aminoalkyl-6,11-dihydro-5H-pyrido(2,3-B)(1,5)benzodia zepin-5-ones and salts thereof
- 专利标题(中): 2-甲基-6-烷基-11-氨基烷基-6,11-二氢-5H-吡啶并(2,3-B)(1,5)苯并二氮杂-5-酮及其盐
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申请号: US837578申请日: 1977-09-28
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公开(公告)号: US4167570A公开(公告)日: 1979-09-11
- 发明人: Gunther Schmidt , Sigfrid Puschmann , Gunther Engelhardt
- 申请人: Gunther Schmidt , Sigfrid Puschmann , Gunther Engelhardt
- 申请人地址: DEX Ingelheim am Rhein
- 专利权人: Boehringer Ingelheim GmbH
- 当前专利权人: Boehringer Ingelheim GmbH
- 当前专利权人地址: DEX Ingelheim am Rhein
- 优先权: DEX2644121 19760930
- 主分类号: A61K31/55
- IPC分类号: A61K31/55 ; A61K31/551 ; A61P11/08 ; A61P11/10 ; C07D213/80 ; C07D471/04
摘要:
Compounds of the formula ##STR1## wherein R.sub.1 --is hydrogen, alkyl of 1 to 6 carbon atoms or benzyl;R.sub.2 --is alkyl of 1 to 6 carbon atoms, cycloalkyl of 5 to 7 carbon atoms or, together with R.sub.1 and the adjacent nitrogen atom, pyrrolidino, piperidino, hexamethyleneimino, morpholino or N'-methyl-piperazino, where each of the heterocycles may have one or two alkyl of 1 to 3 carbon atoms or one or two methoxy substituents attached thereto;R.sub.3,--r.sub.4 and R.sub.5 are each hydrogen or methyl;R.sub.6 --is alkyl of 1 to 4 carbon atoms; andA--is alkylene of 2 to 4 carbon atoms;And non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as bronchospasmolytics and bronchosecretolytics.
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