公开(公告)号：US5393774A

公开(公告)日：1995-02-28

申请号：US187671

申请日：1994-01-27

Applicant: Helmut Pieper ,  Gunther Engelhardt

Inventor： Helmut Pieper ,  Gunther Engelhardt

IPC: A23K1/16 ,  A61K31/275 ,  A61K31/277 ,  A61K31/36 ,  A61P3/06 ,  A61P11/00 ,  A61P11/08 ,  A61P13/02 ,  A61P15/00 ,  A61P21/02 ,  A61P25/02 ,  A61P25/04 ,  A61P29/00 ,  A61P43/00 ,  C07C255/59 ,  C07C271/28 ,  C07C255/50 ,  C07D317/54 ,  C07C28/58

CPC classification number: C07C255/59 ,  A23K20/111 ,  A61K31/275 ,  A61K31/36 ,  C07C271/28

Abstract: The invention relates to phenylethanolamines of general formula ##STR1## wherein R.sub.1 and R.sub.2 are defined as in claim 1, the enantiomers and the acid addition salts thereof, which have valuable pharmacological properties, not only analgesic, antiphlogistic, broncholytic, uterus-spasmolytic, lipolytic effects and an antispastic effect on the cross-striped muscle, but also .beta..sub.2 -mimetic and/or .beta..sub.1 -blocking effects, the use thereof as pharmaceuticals and as performance enhancers and processes for preparing them.

Abstract translation: 本发明涉及通式为“IMAGE”的苯乙醇胺，其中R 1和R 2如权利要求1所定义，其对映体及其酸加成盐具有有价值的药理学性质，不仅止痛，消炎，支气管分解，子宫解痉，脂肪分解 效应和抗交叉效应，而且还具有β2-模拟和/或β1-阻断作用，其作为药物的用途以及用于制备它们的性能增强剂和方法。

公开(公告)号：US5114935A

公开(公告)日：1992-05-19

申请号：US568446

申请日：1990-08-15

Applicant: Helmut Ballhause ,  Gunther Engelhardt ,  Claus A. Landgraf ,  Norbert Mayer ,  Willy Roth ,  Kurt Schumacher ,  Alex Prox

Inventor： Helmut Ballhause ,  Gunther Engelhardt ,  Claus A. Landgraf ,  Norbert Mayer ,  Willy Roth ,  Kurt Schumacher ,  Alex Prox

IPC: A61K31/535 ,  A61P11/14 ,  C07D265/06

CPC classification number: C07D265/06

Abstract: Novel compounds of the general formula ##STR1## which have antitussive activity, wherein R.sub.1 -R.sub.4 are as defined herein.

Abstract translation: 具有镇咳活性的通式为“IMAGE”I的新型化合物，其中R 1 -R 4如本文所定义。

公开(公告)号：US4328235A

公开(公告)日：1982-05-04

申请号：US163965

申请日：1980-06-30

Applicant: Gunter Trummlitz ,  Wolfhard Engel ,  Gunther Schmidt ,  Wolfgang Eberlein ,  Ernst Seeger ,  Gunther Engelhardt ,  Rainer Zimmermann

Inventor： Gunter Trummlitz ,  Wolfhard Engel ,  Gunther Schmidt ,  Wolfgang Eberlein ,  Ernst Seeger ,  Gunther Engelhardt ,  Rainer Zimmermann

IPC: A61K31/425 ,  A61K31/428 ,  A61P25/04 ,  A61P29/00 ,  C07D277/68

CPC classification number: C07D277/68 ,  A61K31/425

Abstract: There are described pharmaceutical compositions containing as active substances benzothiazol-2(3H)-ones of the general formula ##STR1## wherein R represents a hydrogen atom or a methyl, methoxy, or ethoxy group. The pharmaceutical compositions serve as analgesics and antipyretics and possess little or no methemoglobin-forming activity.

Abstract translation: 描述了含有作为活性物质的通式为“IMAGE”的苯并噻唑-2（3H） - 酮的药物组合物，其中R表示氢原子或甲基，甲氧基或乙氧基。 药物组合物用作止痛剂和解热药，并且几乎没有或没有高铁血红蛋白形成活性。

公开(公告)号：US4259336A

公开(公告)日：1981-03-31

申请号：US86743

申请日：1979-10-22

Applicant: Wolfhard Engel ,  Gunter Trummlitz ,  Ernst Seeger ,  Walter Haarmann ,  Gunther Engelhardt ,  Rainer Zimmermann

Inventor： Wolfhard Engel ,  Gunter Trummlitz ,  Ernst Seeger ,  Walter Haarmann ,  Gunther Engelhardt ,  Rainer Zimmermann

IPC: A61K31/54 ,  A61P9/08 ,  A61P9/10 ,  A61P29/00 ,  C07D333/70 ,  C07D513/04 ,  A61K31/38

CPC classification number: C07D513/04 ,  C07D333/70 ,  Y10S514/822

Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, halogen or alkyl of 1 to 3 carbon atoms; R.sub.2 is hydrogen or alkyl of 1 to 3 carbon atoms; andR.sub.3 is aromatic hydrocarbyl of 6 to 10 carbon atoms or an aromatic heterocycle of 2 to 9 carbon atoms and 1 to 2 nitrogen atoms and/or an oxygen or a sulfur atom, where each of said aromatic substituents may in turn be substituted with one or two alkyls of 1 to 6 carbon atoms, halogen, hydroxyl, trifluoromethyl, halophenyl or alkoxy of 1 to 3 carbon atoms;and non-toxic, pharmacologically acceptable salts thereof formed with inorganic or organic bases; the compounds as well as their salts are useful as analgesics, antipyretics, antithrombotic and antiphlogistics.

Abstract translation: 其中R 1是氢，卤素或1至3个碳原子的烷基; R2是氢或1至3个碳原子的烷基; 并且R 3是6至10个碳原子的芳族烃基或2至9个碳原子和1至2个氮原子和/或氧或硫原子的芳族杂环，其中每个所述芳族取代基可以依次被一个 或两个1至6个碳原子的烷基，卤素，羟基，三氟甲基，卤代苯基或具有1至3个碳原子的烷氧基; 和与无机或有机碱形成的无毒的，药理学上可接受的盐; 化合物及其盐可用作镇痛药，解热药，抗血栓和消炎药。

公开(公告)号：US4256747A

公开(公告)日：1981-03-17

申请号：US25718

申请日：1979-03-30

Applicant: Oswald Tauber ,  Gunther Engelhardt ,  Matyas Leitold ,  Gunther Schmidt

Inventor： Oswald Tauber ,  Gunther Engelhardt ,  Matyas Leitold ,  Gunther Schmidt

IPC: A61K31/045 ,  A61K31/19 ,  A61K31/195 ,  A61K31/22 ,  A61K31/405 ,  A61K31/415 ,  A61K31/55 ,  A61K45/00 ,  A61P29/00 ,  C07D471/04 ,  A61K31/495

CPC classification number: A61K31/55 ,  A61K31/60 ,  Y10S514/825 ,  Y10S514/974

Abstract: Pharmaceutical compositions containing a non-steroidal anti-inflammatory compound and 5,11-dihydro-11-[(4-methyl-1-piperazinyl)-acetyl]-6H-pyrido[2,3-b]-[1,4]benzodiazepin-6-one or a non-toxic acid addition salt thereof, and a method of using the same as antiphlogistics; the pyridobenzodiazepinone ingredient effectively suppresses the gastro-intestinal side-effects of the anti-inflammatory ingredient.

公开(公告)号：US4233299A

公开(公告)日：1980-11-11

申请号：US966963

申请日：1978-12-06

Applicant: Gunter Trummlitz ,  Wolfhard Engel ,  Ernst Seeger ,  Gunther Engelhardt

Inventor： Gunter Trummlitz ,  Wolfhard Engel ,  Ernst Seeger ,  Gunther Engelhardt

IPC: A61K31/427 ,  A61K31/54 ,  A61K31/5415 ,  A61P29/00 ,  C07D275/06 ,  C07D279/02 ,  C07D417/12 ,  C07D513/14 ,  A61K31/38

CPC classification number: C07D275/06 ,  C07D279/02 ,  C07D417/12 ,  C07D513/14

Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, methyl or ethyl;R.sub.2 is methyl, ethyl or n-propyl; andY is hydrogen, methyl, methoxy, fluorine or chlorine;and non-toxic, pharmacologically acceptable salts thereof formed with an inorganic or organic base. The compounds as well as their salts are useful as antiphlogistics.

Abstract translation: 其中R 1是氢，甲基或乙基; R2是甲基，乙基或正丙基; Y为氢，甲基，甲氧基，氟或氯; 和与无机或有机碱形成的无毒的，药学上可接受的盐。 化合物及其盐可用作消炎剂。

公开(公告)号：US3992535A

公开(公告)日：1976-11-16

申请号：US626623

申请日：1975-10-29

Applicant: Gunter Trummlitz ,  Helmut Teufel ,  Wolfhard Engel ,  Ernst Seeger ,  Walter Haarmann ,  Gunther Engelhardt

Inventor： Gunter Trummlitz ,  Helmut Teufel ,  Wolfhard Engel ,  Ernst Seeger ,  Walter Haarmann ,  Gunther Engelhardt

IPC: C07D275/06 ,  C07D279/02 ,  C07D417/12 ,  C07D513/04 ,  A61K31/54

CPC classification number: C07D275/06 ,  C07D279/02

Abstract: Compounds of the formula ##SPC1##WhereinR.sub.1 is hydrogen, methyl or ethyl, andAr is phenyl, 3-chlorophenyl, 3-bromophenyl, 2-fluorophenyl, 3-fluorophenyl, 4-fluorophenyl, 3-tolyl, 2-methoxyphenyl, 3-methoxyphenyl, 2-pyridyl, 4-methyl-2-pyridyl, 6-methyl-2-pyridyl, 3-hydroxy-2-pyridyl, 3-pyridyl, 4-pyridyl, 6-chloro-3-pyridazinyl, 2-pyrazinyl, 6-chloro-2-pyrazinyl, 6-chloro-4-pyrimidinyl, 2-thiazolyl, 4-methyl-2-thiazolyl, 4-ethyl-2-thiazolyl, 5-methyl-2-thiazolyl, 5-ethyl-2-thiazolyl, 4,5-dimethyl-2-thiazolyl, 4-ethyl-5-methyl-2-thiazolyl, 5-ethyl-4-methyl-2-thiazolyl, 2-benzothiazolyl, 4,5,6,7-tetrahydro-2-benzothiazolyl, 5,6-dihydro-7H-thiopyrano[4,3-d]thiazol-2-yl, 3-methyl-5-isothiazolyl, 1,3,4-thiadiazolyl, 5-methyl-1,3,4-thiadiazol-2-yl or 5-methyl-3-isoxazolyl,And non-toxic, pharmacologically acceptable salts thereof formed with an inorganic or organic base; the compounds as well as their salts are useful as inhibitors of platelet adhesion and aggregation.

Abstract translation: 式WHERE R1的化合物是氢，甲基或乙基，Ar是苯基，3-氯苯基，3-溴苯基，2-氟苯基，3-氟苯基，4-氟苯基，3-甲苯基，2-甲氧基苯基，3-甲氧基苯基， 2-吡啶基，4-甲基-2-吡啶基，6-甲基-2-吡啶基，3-羟基-2-吡啶基，3-吡啶基，4-吡啶基，6-氯-3-哒嗪基，2-吡嗪基，6-吡啶基， 4-氯-2-吡嗪基，6-氯-4-嘧啶基，2-噻唑基，4-甲基-2-噻唑基，4-乙基-2-噻唑基，5-甲基-2-噻唑基，5-乙基-2-噻唑基， 4,5-二甲基-2-噻唑基，4-乙基-5-甲基-2-噻唑基，5-乙基-4-甲基-2-噻唑基，2-苯并噻唑基，4,5,6,7-四氢-2- 苯并噻唑基，5,6-二氢-7H-噻喃并[4,3-d]噻唑-2-基，3-甲基-5-异噻唑基，1,3,4-噻二唑基，5-甲基-1,3,4-噻二唑基， 噻二唑-2-基或5-甲基-3-异恶唑基，以及与无机或有机碱形成的非毒性，药理学上可接受的盐; 化合物作为它们的盐作为板材粘合和聚集的抑制剂有用。

公开(公告)号：US3987197A

公开(公告)日：1976-10-19

申请号：US577170

申请日：1975-05-14

Applicant: Wolfhard Engel ,  Helmut Teufel ,  Ernst Seeger ,  Josef Nickl ,  Gunther Engelhardt

Inventor： Wolfhard Engel ,  Helmut Teufel ,  Ernst Seeger ,  Josef Nickl ,  Gunther Engelhardt

IPC: C07C45/46 ,  C07C57/58 ,  C07C57/76 ,  C07C63/333 ,  C07C245/14 ,  C07F9/54

CPC classification number: C07C245/14 ,  C07C255/00 ,  C07C45/46 ,  C07C57/58 ,  C07C57/76 ,  C07F9/5407

Abstract: 3-(2'-Fluoro-4-biphenylyl)-butyric acid and salts thereof formed with inorganic or organic bases; the compound as well as its salts are useful as antiphlogistics and antirheumatics.

公开(公告)号：US5648386A

公开(公告)日：1997-07-15

申请号：US346105

申请日：1994-11-29

Applicant: Wolfgang Resemann ,  Adolf Durr ,  Gunther Engelhardt ,  John Frances Quirke

Inventor： Wolfgang Resemann ,  Adolf Durr ,  Gunther Engelhardt ,  John Frances Quirke

IPC: C07C255/59 ,  A23K1/16 ,  A23K1/18 ,  A61K31/00 ,  A61K31/275 ,  A61K31/277 ,  A61P3/00 ,  A61P3/04 ,  A61P11/00 ,  A61P11/06 ,  A61P13/02 ,  A61P15/00 ,  A61P21/02 ,  A61P25/04 ,  A61P29/00 ,  A61P37/08 ,  C07B57/00 ,  C07C253/34 ,  C07C255/49 ,  C07C255/00

CPC classification number: A61K31/275 ,  A23K20/111 ,  A23K50/30 ,  A61K31/277 ,  C07C255/59 ,  Y10S514/826 ,  Y10S514/888 ,  Y10S514/909

Abstract: The invention relates to the separation of enantiomers of cimaterol, (-)-cimaterol, the addition salts thereof and processes for preparing them and their use in pharmaceutical compositions and animal feeds.

Abstract translation: 本发明涉及分离西马特罗，（ - ） - 西马特罗的对映异构体，其加成盐及其制备方法及其在药物组合物和动物饲料中的应用。

公开(公告)号：US5292753A

公开(公告)日：1994-03-08

申请号：US81996

申请日：1993-06-23

Applicant: Wolfgang Resemann ,  Adolf Durr ,  Gunther Engelhardt ,  John F. Quirke

Inventor： Wolfgang Resemann ,  Adolf Durr ,  Gunther Engelhardt ,  John F. Quirke

IPC: C07C255/59 ,  A23K1/16 ,  A23K1/18 ,  A61K31/00 ,  A61K31/275 ,  A61K31/277 ,  A61P3/00 ,  A61P3/04 ,  A61P11/00 ,  A61P11/06 ,  A61P13/02 ,  A61P15/00 ,  A61P21/02 ,  A61P25/04 ,  A61P29/00 ,  A61P37/08 ,  C07B57/00 ,  C07C253/34 ,  C07C255/49 ,  A01N37/34

CPC classification number: A61K31/275 ,  A23K20/111 ,  A23K50/30 ,  A61K31/277 ,  C07C255/59 ,  Y10S514/826 ,  Y10S514/888 ,  Y10S514/909

Abstract: The invention relates to the separation of enantiomers of cimaterol, (-)-cimaterol, the addition salts thereof and processes for preparing them and their use in pharmaceutical compositions and animal feeds.

Abstract translation: 本发明涉及分离西马特罗，（ - ） - 西马特罗的对映异构体，其加成盐及其制备方法及其在药物组合物和动物饲料中的应用。