发明授权
- 专利标题: Prostaglandin I.sub.2 analogues
- 专利标题(中): 前列腺素I2类似物
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申请号: US878571申请日: 1978-02-16
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公开(公告)号: US4178367A公开(公告)日: 1979-12-11
- 发明人: Hayashi Masaki , Yoshinobu Arai , Yoshitaka Konishi , Katsuichi Shimoji , Shuichi Ohuchida , Hiroyuki Ito , Hirohisa Wakatsuka
- 申请人: Hayashi Masaki , Yoshinobu Arai , Yoshitaka Konishi , Katsuichi Shimoji , Shuichi Ohuchida , Hiroyuki Ito , Hirohisa Wakatsuka
- 申请人地址: JPX Osaka
- 专利权人: Ono Pharmaceutical Co. Ltd.
- 当前专利权人: Ono Pharmaceutical Co. Ltd.
- 当前专利权人地址: JPX Osaka
- 优先权: JPX52/017141 19770221; JPX52/030494 19770322
- 主分类号: C07C405/00
- IPC分类号: C07C405/00 ; C07D307/937 ; C07F9/40 ; A61K31/34 ; C07D307/93
摘要:
Prostaglandin I.sub.2 analogues of the formula: ##STR1## (wherein Y represents trans-vinylene or ethylene, R.sup.1 represents hydrogen or an alkyl group containing from 1 to 12 carbon atoms, R.sup.2 represents hydrogen, methyl or ethyl, R.sup.3 represents a single bond, or an alkylene group containing from 1 to 4 carbon atoms, R.sup.4, R.sup.5 and R.sup.6, which may be the same or different, each represent hydrogen or an alkyl group containing from 1 to 8 carbon atoms, n represents 3, 4, 5 or 6, the wavy line attached to the carbon atoms in positions 11 and 15 depicted in the formula represents .alpha.- or .beta.-configuration or mixtures thereof, and the double bond between C.sub.6 -C.sub.6 is Z or E) are new compounds possessing pharmacological properties typical of prostaglandins, for example PGI.sub.2.
公开/授权文献
- US5806456A Variable attact angle marine spade anchors 公开/授权日:1998-09-15
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