发明授权
- 专利标题: 15-Cycloalkyl-prostaglandin derivatives
- 专利标题(中): 15-环烷基 - 前列腺素衍生物
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申请号: US857341申请日: 1977-12-05
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公开(公告)号: US4180675A公开(公告)日: 1979-12-25
- 发明人: Masaki Hayashi , Seiji Kori , Isao Ohyama , Sadahiko Iguchi , Takanori Okada
- 申请人: Masaki Hayashi , Seiji Kori , Isao Ohyama , Sadahiko Iguchi , Takanori Okada
- 申请人地址: NJ Morris Plains
- 专利权人: Warner-Lambert Company
- 当前专利权人: Warner-Lambert Company
- 当前专利权人地址: NJ Morris Plains
- 优先权: GBX30072/75 19750717; GBX18651/76 19760506
- 主分类号: C07C405/00
- IPC分类号: C07C405/00 ; C07D309/12 ; C07F9/40 ; C08B37/00 ; C07C177/00
摘要:
The present invention relates to 15-cycloalkyl-prostaglandins of the formula: ##STR1## wherein A represents a grouping of the formula: ##STR2## W represents ethylene or trans-vinylene, X represents ethylene or cis-vinylene, Y represents ethylene or trans-vinylene, R represents a hydrogen atom or a straight- or branched-chain alkyl group containing from 1 to 12 carbon atoms, R.sup.1 represents a hydrogen atom or a methyl or ethyl group, R.sup.2 represents a straight- or branched-chain alkyl group containing from 2 to 8 carbon atoms or a phenyl group unsubstituted or substituted by an alkyl group containing from 1 to 3 carbon atoms, R.sup.3 represents a hydrogen atom or a straight- or branched-chain alkyl group containing from 1 to 3 carbon atoms, and n represents 4 or 5 and cyclodextrin clathrates of such acids and esters and, when R represents a hydrogen atom, non-toxic salts thereof.These new compounds exhibit characteristic prostaglandin-like activities.
公开/授权文献
- US4686972A Surgical deflector and drilling guide 公开/授权日:1987-08-18