发明授权
US4191739A Antigen-antibody reaction assay employing particle aggregation and
resistive pulse analysis
失效
抗原 - 抗体反应测定采用粒子聚集和电阻脉冲分析
- 专利标题： Antigen-antibody reaction assay employing particle aggregation and resistive pulse analysis
- 专利标题（中）： 抗原 - 抗体反应测定采用粒子聚集和电阻脉冲分析
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申请号： US842952申请日： 1977-10-17
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公开(公告)号： US4191739A公开(公告)日： 1980-03-04
- 发明人: Egidijus E. Uzgiris , Ralph W. De Blois
- 申请人： Egidijus E. Uzgiris , Ralph W. De Blois
- 申请人地址： NY Schenectady
- 专利权人： General Electric Company
- 当前专利权人： General Electric Company
- 当前专利权人地址： NY Schenectady
- 主分类号： G01N15/12
- IPC分类号： G01N15/12 ; G01N33/487 ; G01N33/543 ; G01N27/00 ; G01N27/26 ; G01N31/00 ; G01N33/16
摘要：
In a mixture of two antibody-coated latex particle suspensions, the particles in each suspension being of a different size, respectively, absence of antigen specific to the antibody in the mixture leaves multiplets only of one and the other sizes of particles. Presence of antigen in the mixture results in large particle/small particle coupling, which is detected by the resistive pulse method and indicates that an antigen-antibody reaction has occurred.
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