A control and monitoring system for an oxygen generation device having a plurality of chemical oxygen generation elements sequentially decomposed to continuously generate oxygen. The control and monitoring system has a temperature sensor operatively coupled to each of the chemical oxygen generation elements, except the one to be ignited last, for producing a first control signal in response to the heat generated by the chemical oxygen generation elements during decomposition, a gas flow sensor disposed in the oxygen outlet has the oxygen generation elements and responsive to a flow rate less than a predetermined minimum flow rate to produce a second control signal, a sequential ignition mechanism operated on the occurrence of both the first control signal and the second control signal, as an ignition signal for igniting the oxygen generation elements one after another, and an alarm operative in response to the second control signal after a time interval of not less than a predetermined magnitude for indicating the interruption of oxygen generation for an abnormally long time interval.Preferably, light emitter indicator means are provided to indicate ignition of the corresponding oxygen generating element.