发明授权
US4230859A Process for the preparation of N-substituted esters of
9,10-dihydrolysergicacids
失效
制备9,10-二氢赖氨酸的N-取代酯的方法
- 专利标题： Process for the preparation of N-substituted esters of 9,10-dihydrolysergicacids
- 专利标题（中）： 制备9,10-二氢赖氨酸的N-取代酯的方法
-
申请号： US922692申请日： 1978-07-07
-
公开(公告)号： US4230859A公开(公告)日： 1980-10-28
- 发明人: Rudolf Rucman
- 申请人： Rudolf Rucman
- 申请人地址： YUX Ljubljana
- 专利权人： LEK, tovarna farmacevtskih in kemicnih izdelkov, n.sol.o.
- 当前专利权人： LEK, tovarna farmacevtskih in kemicnih izdelkov, n.sol.o.
- 当前专利权人地址： YUX Ljubljana
- 优先权： YUX1819/77 19770721
- 主分类号： C07D457/02
- IPC分类号： C07D457/02 ; A61K31/48 ; B01J31/00 ; C07B61/00 ; C07D457/04
摘要：
A process for the preparation of N-substituted esters of 9,10-dihydrolysergic acids of the formula: ##STR1## wherein R.sub.1 is an alkyl group of 1-5 carbon atoms, an alkenyl group of 2-5 carbon atoms or a cycloalkyl group of 3-5 carbon atoms,R.sub.2 is hydrogen or an alkoxy group of 1-3 carbon atoms andX' is hydrogen or halogen,characterized in that esterified 9,10-dihydrolysergic acids of the formula: ##STR2## wherein R is hydrogen or a hydrolyzable organic group,X' is hydrogen or halogen, andR.sub.2 has the meaning as stated above,are reacted with a compound of the formula:R.sub.1 Y (III)whereinR.sub.1 has the meaning as stated above,Y is halogen or sulphate,in the presence of a catalyst for phase transition in the presence of aqueous alkali medium in an inert organic solvent immiscible with water, and certain novel esters obtained thereby.
公开/授权文献
- US5975802A Pipeline laying apparatus 公开/授权日：1999-11-02
信息查询
