发明授权
- 专利标题: Cis-diammineplatinum(II) orthophosphate complexes
- 专利标题(中): 顺式二磷酸铂(II)正磷酸盐络合物
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申请号: US17994申请日: 1979-03-07
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公开(公告)号: US4248840A公开(公告)日: 1981-02-03
- 发明人: James D. Hoeschele , Alan R. Amundsen
- 申请人: James D. Hoeschele , Alan R. Amundsen
- 申请人地址: NJ Iselin
- 专利权人: Engelhard Minerals and Chemicals Corporation
- 当前专利权人: Engelhard Minerals and Chemicals Corporation
- 当前专利权人地址: NJ Iselin
- 主分类号: A61K31/28
- IPC分类号: A61K31/28 ; A61K33/42 ; A61P35/00 ; C01B21/097 ; C01B25/37 ; C07F15/00 ; C01B21/06 ; C01B25/00
摘要:
Cis-diammineplatinum(II) orthophosphate complexes are prepared by reaction of diaquo-cis-diammineplatinum(II) salts with alkali metal orthophosphates. The resulting complexes possess pronounced anti-tumor activity in mice and low toxicity; consequently, they have high therapeutic indices.
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