发明授权
US4263308A N-Alkoxy-dithienylpiperidines, pharmaceutical compositions thereof and
methods of use thereof
失效
N-烷氧基 - 二噻吩基哌啶,其药物组合物及其使用方法
- 专利标题: N-Alkoxy-dithienylpiperidines, pharmaceutical compositions thereof and methods of use thereof
- 专利标题(中): N-烷氧基 - 二噻吩基哌啶,其药物组合物及其使用方法
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申请号: US112100申请日: 1980-01-14
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公开(公告)号: US4263308A公开(公告)日: 1981-04-21
- 发明人: Jurgen Engel , Axel Kleemann , Ute-Achterrath Tuckermann , Klaus Thiemer
- 申请人: Jurgen Engel , Axel Kleemann , Ute-Achterrath Tuckermann , Klaus Thiemer
- 申请人地址: DEX Frankfurt
- 专利权人: Degussa Aktiengesellschaft
- 当前专利权人: Degussa Aktiengesellschaft
- 当前专利权人地址: DEX Frankfurt
- 优先权: GBX1660/79 19790117
- 主分类号: C07D409/14
- IPC分类号: C07D409/14 ; A61K31/4433 ; A61K31/445 ; C07D333/00 ; C07D417/14
摘要:
There are prepared compounds of the formula ##STR1## where R.sub.1 is hydrogen or hydroxy, R.sub.2 is hydrogen or R.sub.1 and R.sub.2 together represent a second bond between the carbon atoms carrying R.sub.1 and R.sub.2, Alk is a C.sub.2 -C.sub.6 alkylene group, R.sub.3 is a C.sub.3 -C.sub.8 -cycloalkyl group, a C.sub.1 -C.sub.6 -alkyl group, a C.sub.1 -C.sub.6 -hydroxyalkyl group or a C.sub.2 -C.sub.6 -hydroxyalkoxy-C.sub.1 -C.sub.6 -alkyl group and the groups R.sub.4, R.sub.5, R.sub.6 and R.sub.7 are the same or different and are hydrogen, C.sub.1 -C.sub.6 -alkyl group or halogen atoms, their N-oxides, their quaternary salts and their acid addition salts. There are also described processes for their production. The compounds have a strong bronchospasmolytic activity, antianaphylactic activity and an antihistamine-antiserotonine activity.
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