发明授权
- 专利标题： 2-Methyl-5-(2-hydroxystyryl)-1,3,4-thiadiazole
- 专利标题（中）： 2-甲基-5-（2-羟基苯乙烯基）-1,3,4-噻二唑
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申请号： US30886申请日： 1979-04-17
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公开(公告)号： US4263430A公开(公告)日： 1981-04-21
- 发明人: Helmut Hagen , Peter C. Thieme , Albrecht Franke
- 申请人： Helmut Hagen , Peter C. Thieme , Albrecht Franke
- 申请人地址： DEX
- 专利权人： BASF Aktiengesellschaft
- 当前专利权人： BASF Aktiengesellschaft
- 当前专利权人地址： DEX
- 优先权： DEX2818766 19780428
- 主分类号： C07D285/12
- IPC分类号： C07D285/12 ; C07F9/6539
摘要：
2-Methyl-5-(2-hydroxystyryl)-1,3,4-thiadiazole of the formula ##STR1## and processes for its preparation by condensing salicylaldehyde with 2,5-dimethyl-1,3,4-thiadiazole or 2-methyl-5-(triphenylphosphine-methylene)-1,3,4-thiadiazole. 2-Methyl-5-(2-hydroxystyryl)-1,3,4-thiadiazole is a valuable intermediate for the preparation of pharmacologically active compounds; for example the alkylamino-hydroxypropyl ethers can, because of their .beta.-sympatholytic action, be used as drugs for the treatment of coronary diseases of the heart, cardiac arrhythmias and hypertonia.