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85 条记录 (耗时 0.021 秒)

    2-Methyl-5-(2-hydroxystyryl)-1,3,4-thiadiazole
    2.
    发明授权
    2-Methyl-5-(2-hydroxystyryl)-1,3,4-thiadiazole 失效
    2-甲基-5-（2-羟基苯乙烯基）-1,3,4-噻二唑

    公开(公告)号：US4263430A

    公开(公告)日：1981-04-21

    申请号：US30886

    申请日：1979-04-17

    申请人： Helmut Hagen ,  Peter C. Thieme ,  Albrecht Franke

    发明人： Helmut Hagen ,  Peter C. Thieme ,  Albrecht Franke

    IPC分类号： C07D285/12 ,  C07F9/6539

    CPC分类号： C07D285/12 ,  C07F9/65395

    摘要： 2-Methyl-5-(2-hydroxystyryl)-1,3,4-thiadiazole of the formula ##STR1## and processes for its preparation by condensing salicylaldehyde with 2,5-dimethyl-1,3,4-thiadiazole or 2-methyl-5-(triphenylphosphine-methylene)-1,3,4-thiadiazole. 2-Methyl-5-(2-hydroxystyryl)-1,3,4-thiadiazole is a valuable intermediate for the preparation of pharmacologically active compounds; for example the alkylamino-hydroxypropyl ethers can, because of their .beta.-sympatholytic action, be used as drugs for the treatment of coronary diseases of the heart, cardiac arrhythmias and hypertonia.

    摘要翻译： 式（1）的2-甲基-5-（2-羟基苯乙烯基）-1,3,4-噻二唑及其制备方法是将水杨醛与2,5-二甲基-1,3,4-噻二唑 或2-甲基-5-（三苯基膦 - 亚甲基）-1,3,4-噻二唑。 2-甲基-5-（2-羟基苯乙烯基）-1,3,4-噻二唑是制备药理活性化合物的有价值的中间体; 例如，烷基氨基 - 羟丙基醚可以由于其β - 溶血性作用而被用作治疗心脏冠状动脉疾病，心律失常和高渗性的药物。

    Method of producing 2-alkyl-3-(4,5-dihydroisoxazole-3-yl)-halobenzenes
    7.
    发明授权
    Method of producing 2-alkyl-3-(4,5-dihydroisoxazole-3-yl)-halobenzenes 有权
    2-烷基-3-（4,5-二氢异恶唑-3-基） - 卤代苯的制备方法

    公开(公告)号：US06548677B1

    公开(公告)日：2003-04-15

    申请号：US09856037

    申请日：2001-05-17

    申请人： Michael Rack ,  Norbert Götz ,  Helmut Hagen ,  Wolfgang von Deyn ,  Ernst Baumann ,  Rene Lochtman ,  Joachim Gebhardt

    发明人： Michael Rack ,  Norbert Götz ,  Helmut Hagen ,  Wolfgang von Deyn ,  Ernst Baumann ,  Rene Lochtman ,  Joachim Gebhardt

    IPC分类号： C07D26118

    CPC分类号： C07D261/04

    摘要： A novel process for preparing the compounds of the formula I where: n is 0, 1 or 2; R1, R2 are C1-C6-alkyl; R3, R4, R5 are hydrogen or C1-C6-alkyl, or R4 and R5 together form a bond; R6 is Cl, Br, which comprises a synthesis sequence starting from 1,2-dialkylbenzenes of the formula II with subsequent halogenation to give 3,6-dihalo-1,2-dialkylbenzenes, haloalkylation to give benzyl bromides, oxidation to give benzaldehydes, oximation, reaction with alkenes to give isoxazoles, conversion into thioethers and, if appropriate, oxidation to give sulfenyl or sulfonyl derivatives of the formula I.

    摘要翻译： 一种制备式I化合物的新方法，其中n为0,1或2; R 1，R 2为C 1 -C 6 - 烷基; R 3，R 4，R 5为氢或C 1 -C 6烷基，或者R 4和R 5一起形成 R 6是Cl，Br，其包含从式II的1,2-二烷基苯开始的合成序列，随后卤化以得到3,6-二卤代-1,2-二烷基苯，卤代烷基化得到苄基溴，氧化得到 苯甲醛，肟化，与烯烃的反应得到异恶唑，转化成硫醚，如果合适，氧化得到式I的磺酰基或磺酰基衍生物。

    Herbicides containing substituted 2-aminothiophenes
    8.
    发明授权
    Herbicides containing substituted 2-aminothiophenes 失效

    公开(公告)号：US5422335A

    公开(公告)日：1995-06-06

    申请号：US70389

    申请日：1993-06-07

    申请人： Helmut Hagen ,  Gerhard Nilz ,  Helmut Walter ,  Andreas Landes

    发明人： Helmut Hagen ,  Gerhard Nilz ,  Helmut Walter ,  Andreas Landes

    IPC分类号： A01N25/32 ,  A01N35/06 ,  A01N39/02 ,  A01N43/10 ,  C07D333/38 ,  C07D333/68 ,  C07D333/70 ,  C07D409/04 ,  C07D409/12 ,  C07D417/12 ,  A01N43/12 ,  A01N47/24 ,  C07D333/54

    CPC分类号： C07D409/04 ,  A01N25/32 ,  C07D333/38 ,  C07D333/68 ,  C07D409/12 ,  C07D417/12

    摘要： A herbicidal composition containing one or more substituted 2-aminothiophenes of the formula I ##STR1## where R.sup.1 and R.sup.2 together from a C.sub.4 -alkylene chain to which a benzene ring may be fused,R.sup.3 is --CN or CX--R.sup.6, where R.sup.6 is hydroxyl, C.sub.1 -C.sub.4 -alkoxy or amino,R.sup.4 is hydrogen or a phenyl group which may carry one or two nitro radicals,--PO(OR.sup.8).sub.2, --CX--R.sup.9, --SO.sub.2 R.sup.10, --CX--N(H) --CO--R.sup.8 or --CX--N(R.sup.7)--SO.sub.2 --R.sup.11,whereR.sup.8 is hydrogen, C.sub.1 -C.sub.4 -alkyl or phenyl groupR.sup.9 is C.sub.1 -C.sub.20 -alkyl, partially or completely halogenated C.sub.1 -C.sub.6 -alkyl, C.sub.2 -C.sub.6 -alkenyl, C.sub.6 -cycloalkyl, or amino, C.sub.1 -C.sub.4 -alkylamino, C.sub.3 -C.sub.8 -cycloalkylamino, phenyl or phenylamino, where the aromatic moiety may carry at least one of nitro and halogen;R.sup.10 is C.sub.1 -C.sub.4 -alkyl or phenyl, which may carry one C.sub.1 -C.sub.4 -alkyl radical;R.sup.11 is pyrrolidin-1-yl, piperidin-1-yl, morpholin-4-yl or piperazin-1-yl, where the heterocyclic structures may carry one C.sub.1 -C.sub.4 -group;R.sup.5 is hydrogen;orR.sup.4 and R.sup.5 together form a group .dbd.CR.sup.12 R.sup.13 or --CO--W--CO--, where R.sup.12 is hydrogen, amino, C.sub.1 -C.sub.4 -alkylamino or C.sub.3 -C.sub.8 -cycloalkylamino;R.sup.13 is amino, C.sub.3 -C.sub.8 -cycloalkylamino, phenyl or pyridyl, where the two last mentioned substituents may carry at least one halogen or nitro radicals;W is an ethylene or ethenylene bridge, or a 6-membered 1,2-C-bonded aromatic bridge where these bridge members may carry, on each substitutable carbon atom, at least one halogena 5-membered or 6-membered 1,2-C-bonded cycloalkylene or cycloalkenylene bridge,and the basic salts of the compounds I in which R.sup.3 is hydroxycarbonyl or hydroxythiocarbonyl, and the acidic salts of the compounds I which contain a basic nitrogen atom, as antagonistic compoundsand one or more herbicidal active ingredients from the group consisting ofthe cyclohexenone derivatives of the formula III ##STR2##

    2-amino-4-trichloropyridine derivatives
    9.
    发明授权
    2-amino-4-trichloropyridine derivatives 失效
    2-氨基-4-三氯吡啶衍生物

    公开(公告)号：US5216171A

    公开(公告)日：1993-06-01

    申请号：US681254

    申请日：1991-04-08

    申请人： Helmut Hagen ,  Hans Ziegler ,  Juergen Pfister ,  Gerhard Nilz ,  Gisela Lorenz ,  Juergen Dressel

    发明人： Helmut Hagen ,  Hans Ziegler ,  Juergen Pfister ,  Gerhard Nilz ,  Gisela Lorenz ,  Juergen Dressel

    IPC分类号： C05G3/08 ,  C07D213/74 ,  C07D213/75 ,  C07D213/76 ,  C07D401/04 ,  C07F9/58

    CPC分类号： C07D213/74 ,  C07D213/75 ,  C07D213/76 ,  C07D401/04 ,  C07F9/588 ,  Y02P60/218 ,  Y10S106/90

    摘要： 2-Amino-4-trichloromethylpyridines of the general formula I ##STR1## where R.sup.1 is hydrogen or C.sub.1 -C.sub.8 -alkyl,R.sup.2 is C.sub.1 -C.sub.8 -alkyl, C.sub.5 -C.sub.8 -cycloalkyl, C.sub.2 -C.sub.4 -alkenyl or phenyl, benzyl or phenylsulfonyl,--CX--R.sup.3, --SO.sub.2 R.sup.3 or --PX(OR.sup.4).sub.2 orR.sup.1 and R.sup.2 together form .dbd.CR.sup.5 R.sup.6 or --CO--Z--CO--,X is oxygen or sulfur,R.sup.3 is C.sub.1 -C.sub.20 -alkyl, C.sub.2 -C.sub.6 -alkenyl, amino, C.sub.1 -C.sub.6 -alkylamino, di-C.sub.1 -C.sub.6 -alkylamino, morpholino, piperidino, pyrazolidino or C.sub.1 -C.sub.8 -alkylcarbonylamino, substituted or unsubstituted phenylamino or benzylamino,R.sup.4 is C.sub.1 -C.sub.8 -alkyl, C.sub.1 -C.sub.8 -haloalkyl or substituted or unsubstituted phenyl,R.sup.5 is hydrogen, C.sub.1 -C.sub.4 -alkyl, or substituted or unsubstituted phenyl,R.sup.6 is substituted or unsubstituted phenyl,Z is substituted or unsubstituted ethylene which may be part of a substituted or unsubstituted cycloalkyl or cycloalkylene radical, substituted or unsubstituted ethenylene which may be part of a substituted or unsubstituted aromatic or heteroaromatic ring, and Z is not part of an unsubstituted phenyl radical, agriculturally useful salts thereof, processes for their preparation and the use thereof as nitrification inhibitors.

    摘要翻译： 通式I的2-氨基-4-三氯甲基吡啶其中R1是氢或C1-C8-烷基，R2是C1-C8-烷基，C5-C8-环烷基，C2-C4-烯基或苯基，苄基 或苯基磺酰基，-CX-R3，-SO2R3或-PX（OR4）2或R1和R2一起形成= CR5R6或-CO-Z-CO-，X是氧或硫，R3是C1-C20-烷基，C2- C 1 -C 6 - 烯基，氨基，C 1 -C 6 - 烷基氨基，二-C 1 -C 6烷基氨基，吗啉代，哌啶子基，吡唑烷基或C 1 -C 8烷基羰基氨基，取代或未取代的苯基氨基或苄基氨基，R 4是C 1 -C 8烷基， 卤代烷基或取代或未取代的苯基，R 5是氢，C 1 -C 4烷基或取代或未取代的苯基，R 6是取代或未取代的苯基，Z是可以是取代或未取代的环烷基或环亚烷基的一部分的取代或未取代的乙烯 取代或未取代的亚乙烯基，其可以是取代或未取代的芳族或杂芳族环的一部分，Z不是未取代的苯基的一部分，农业 其文化上有用的盐，其制备方法及其作为硝化抑制剂的用途。