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US4272543A Pharmacologically active 4,5-diaryl-2-substituted-imidazoles 失效
药理活性的4,5-二芳基-2-取代的咪唑

Pharmacologically active 4,5-diaryl-2-substituted-imidazoles
摘要:
Imidazole derivatives of the formula ##STR1## wherein AR.sub.1 and AR.sub.2 are independently each phenyl; phenyl substituted by halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy or C.sub.2-6 dialkylamino; pyridyl; furyl; or thienyl; with the proviso that AR.sub.1 and AR.sub.2 are not both unsubstituted phenyl;R.sub.1 is hydrogen, alkyl of 1-4 carbon atoms or alkyl of 1-4 carbon atoms substituted by hydroxy, C.sub.1-4 alkoxy or C.sub.1-6 alkanoyloxy;n is 0, 1 or 2; andZ is cyano; alkynyl of 2-6 carbon atoms; cycloalkyl of 3-8 carbon atoms; cycloalkyl of 3-8 carbon atoms substituted by hydroxy, acyloxy, hydroxymethyl or acyloxymethyl, "acyl" in both cases being the acyl group of a hydrocarbon, aliphatic C.sub.1-6 carboxylic acid or of benzoic acid; or alkyl of 1-4 carbon atoms substituted by cyano, phenyl or cycloalkyl of 3-6 carbon atoms;or physiologically acceptable salts thereof with an acid, have valuable pharmacological properties.
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