发明授权
- 专利标题: Pharmacologically active 4,5-diaryl-2-substituted-imidazoles
- 专利标题(中): 药理活性的4,5-二芳基-2-取代的咪唑
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申请号: US107802申请日: 1979-12-27
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公开(公告)号: US4272543A公开(公告)日: 1981-06-09
- 发明人: Ulrich Niedballa , Irmgard Bottcher
- 申请人: Ulrich Niedballa , Irmgard Bottcher
- 申请人地址: DEX Berlin and Bergkamen
- 专利权人: Schering, Aktiengesellschaft
- 当前专利权人: Schering, Aktiengesellschaft
- 当前专利权人地址: DEX Berlin and Bergkamen
- 优先权: DEX2856909 19781228
- 主分类号: A61K31/415
- IPC分类号: A61K31/415 ; A61P29/00 ; A61P37/08 ; C07D233/84 ; C07D401/14 ; C07D405/04 ; C07D409/04
摘要:
Imidazole derivatives of the formula ##STR1## wherein AR.sub.1 and AR.sub.2 are independently each phenyl; phenyl substituted by halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy or C.sub.2-6 dialkylamino; pyridyl; furyl; or thienyl; with the proviso that AR.sub.1 and AR.sub.2 are not both unsubstituted phenyl;R.sub.1 is hydrogen, alkyl of 1-4 carbon atoms or alkyl of 1-4 carbon atoms substituted by hydroxy, C.sub.1-4 alkoxy or C.sub.1-6 alkanoyloxy;n is 0, 1 or 2; andZ is cyano; alkynyl of 2-6 carbon atoms; cycloalkyl of 3-8 carbon atoms; cycloalkyl of 3-8 carbon atoms substituted by hydroxy, acyloxy, hydroxymethyl or acyloxymethyl, "acyl" in both cases being the acyl group of a hydrocarbon, aliphatic C.sub.1-6 carboxylic acid or of benzoic acid; or alkyl of 1-4 carbon atoms substituted by cyano, phenyl or cycloalkyl of 3-6 carbon atoms;or physiologically acceptable salts thereof with an acid, have valuable pharmacological properties.
公开/授权文献
- US5447339A Pipe for carrying fluids, particularly hydrocarbons 公开/授权日:1995-09-05
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