发明授权
- 专利标题: Antiulcer phenoxypropylamine derivatives
- 专利标题(中): 抗溃疡苯氧基丙胺衍生物
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申请号: US164017申请日: 1980-06-30
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公开(公告)号: US4293557A公开(公告)日: 1981-10-06
- 发明人: Kenyu Shibata , Toshihisa Itaya , Nobuaki Yamakoshi , Shigeru Kurata , Naoyuki Koizumi , Masaaki Tarutani , Hideki Sakuma , Kunihiro Konishi
- 申请人: Kenyu Shibata , Toshihisa Itaya , Nobuaki Yamakoshi , Shigeru Kurata , Naoyuki Koizumi , Masaaki Tarutani , Hideki Sakuma , Kunihiro Konishi
- 申请人地址: JPX Tokyo
- 专利权人: Teikoku Hormone Mfg. Co., Ltd.
- 当前专利权人: Teikoku Hormone Mfg. Co., Ltd.
- 当前专利权人地址: JPX Tokyo
- 优先权: JPX54-83426 19790703; JPX55-19088 19800220
- 主分类号: C07C235/08
- IPC分类号: C07C235/08 ; C07D207/12 ; C07D209/48 ; C07D211/22 ; C07D211/42 ; C07D211/44 ; C07D295/096 ; A61K31/445 ; C07D295/14
摘要:
Phenoxypropylamine derivatives of the general formula ##STR1## wherein R.sub.1 represents a hydrogen atom or a methyl or ethyl group, R.sub.2 and R.sub.3, independently from each other, represent a lower alkyl group, or together form a linear alkylene group having 4 to 7 carbon atoms which may be optionally substituted by a hydroxyl or hydroxymethyl group, and R.sub.4 represents a hydrogen atom or a group of the formula --R.sub.5 --Z in which R.sub.5 represents a lower alkylene group, and Z represents a hydrogen atom or an amino, mono- or di-(lower alkyl)-amino, hydrdoxy lower alkylamino, lower alkanoylamino, hydroxyl, lower alkoxy, lower alkanoyloxy, phenoxy, halophenoxy, benzoyloxy or halobenzoyloxy group, andthe salts thereof; to a process for production thereof; and to their medicinal use, particularly to antiulcer agents comprising these phenoxypropylamine derivatives or their salts.
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