发明授权
- 专利标题: Process for the preparation of 2-nitrobenzaldehyde
- 专利标题(中): 制备2-硝基苯甲醛的方法
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申请号: US125617申请日: 1980-02-28
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公开(公告)号: US4297519A公开(公告)日: 1981-10-27
- 发明人: Werner Ertel
- 申请人: Werner Ertel
- 申请人地址: DEX Leverkusen
- 专利权人: Bayer Aktiengesellschaft
- 当前专利权人: Bayer Aktiengesellschaft
- 当前专利权人地址: DEX Leverkusen
- 优先权: DEX2808930 19780302
- 主分类号: C07C205/44
- IPC分类号: C07C205/44 ; C07C45/28 ; C07C47/54 ; C07C67/00 ; C07C201/00
摘要:
A process provided for the production of 2-nitrobenzaldehyde from 2-nitrotoluene, in which 2-nitrotoluene is converted, by bromination by a radical mechanism, to 2-nitrobenzyl bromide in the form of a bromination oil containing 20 to 50% or more of 2-nitrobenzyl bromide, and the bromination oil is oxidized directly with a mixture of dimethylsulphoxide and sodium bicarbonate in a weight ratio of 3:1 to 10:1 at temperatures of up to 100.degree. C. and the 2-nitrobenzaldehyde is subsequently isolated via the bisulphite adduct, to give 2-nitrobenzaldehyde in high purity and high yield. The process also has the advantage of a very short reaction time. The 2-nitrobenzaldehyde produced is an important intermediate, for example in the production of pharmaceutically active 1,4-dihydropyridines.
公开/授权文献
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