发明授权
- 专利标题: Method of producing hepatitis B surface antigen
- 专利标题(中): 生产乙型肝炎表面抗原的方法
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申请号: US90169申请日: 1979-11-02
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公开(公告)号: US4301250A公开(公告)日: 1981-11-17
- 发明人: William J. McAleer , Henry Z. Markus
- 申请人: William J. McAleer , Henry Z. Markus
- 申请人地址: NJ Rahway
- 专利权人: Merck & Co., Inc.
- 当前专利权人: Merck & Co., Inc.
- 当前专利权人地址: NJ Rahway
- 主分类号: C12N7/00
- IPC分类号: C12N7/00 ; A61K39/29 ; C07K14/02 ; C12N5/02 ; C12M3/04 ; C12P21/00
摘要:
Hepatitis B surface antigen (HB.sub.s Ag) is produced in vitro in high titer and purity from tissue cultures of cells that shed HB.sub.s Ag by growing the cells with a first incubation at elevated temperature followed by a second incubation at a lower elevated temperature.
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