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发明授权
US4301300A Sulfonamide intermediates for adrenergic blocking agents 失效
磺酰胺中间体用于肾上腺素能阻断剂

Sulfonamide intermediates for adrenergic blocking agents
摘要：
There are disclosed compounds of the formula ##STR1## wherein R.sub.1 is selected from the group consisting of lower alkyl; R.sub.8 is selected from the group consisting of --O--(CH.sub.2).sub.n -- wherein n is 2 to 20, ##STR2## and R.sub.6 is selected from the group consisting of hydrogen or lower alkoxy, and ##STR3## wherein R.sub.1 is selected from the group consisting of lower alkyl; R.sub.8 is selected from the group consisting of --O--(CH.sub.2).sub.n -- wherein n is 2 to 20, ##STR4## and R.sub.6 is selected from the group consisting of hydrogen or lower alkoxy and racemates thereof.There are also disclosed processes and intermediates utilized to produce the end products.The end products have utility as agents exhibiting both .alpha. and selective .beta. adrenergic blocking action.
摘要（中）：

公开了式IMA的化合物，其中R 1选自低级烷基; R 8选自-O-（CH 2）n - ，其中n为2至20，且R 6选自氢或低级烷氧基，且其中R 1选自 低级烷基; R 8选自-O-（CH 2）n - ，其中n为2至20，且R 6选自氢或其低级烷氧基及其外消旋体。 还公开了用于生产最终产品的方法和中间体。 最终产品具有作为显示α和选择性β肾上腺素能阻断作用的药剂的效用。

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