发明授权
US4321196A Bis-esters of methanediol with acetonides of ampicillin or amoxicillin
and penicillanic acid 1,1-dioxide
失效
甲硫氨酸的双酯与氨苄青霉素或阿莫西林的丙酮化合物和青霉烷酸1,1-二氧化物
- 专利标题： Bis-esters of methanediol with acetonides of ampicillin or amoxicillin and penicillanic acid 1,1-dioxide
- 专利标题（中）： 甲硫氨酸的双酯与氨苄青霉素或阿莫西林的丙酮化合物和青霉烷酸1,1-二氧化物
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申请号： US246504申请日： 1981-03-23
-
公开(公告)号： US4321196A公开(公告)日： 1982-03-23
- 发明人: Thomas C. Crawford
- 申请人： Thomas C. Crawford
- 申请人地址： NY New York
- 专利权人： Pfizer Inc.
- 当前专利权人： Pfizer Inc.
- 当前专利权人地址： NY New York
- 主分类号： C07D499/00
- IPC分类号： C07D499/00 ; C07D499/32 ; C07D499/80
摘要：
Bis-esters of methanediol wherein one hydroxy group of the methanediol is esterified with the carboxy group of hetacillin (or of the p-hydroxy analog of hetacillin) and the other hydroxy group of the methanediol is esterified with penicillanic acid 1,1-dioxide. These orally effective compounds have a particularly broad spectrum of antibacterial activity in mammals, and have an unusually long serum half-life.
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