发明授权
- 专利标题： Process for producing antibiotic nanaomycin E
- 专利标题（中）： 生产抗生素纳米霉素E的方法
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申请号： US276432申请日： 1981-06-22
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公开(公告)号： US4353986A公开(公告)日： 1982-10-12
- 发明人: Satoshi Omura , Haruo Tanaka , Itaru Takahashi , Shinzo Ishii , Kazuyuki Mineura , Kunikatsu Shirahata , Masaji Kasai
- 申请人： Satoshi Omura , Haruo Tanaka , Itaru Takahashi , Shinzo Ishii , Kazuyuki Mineura , Kunikatsu Shirahata , Masaji Kasai
- 申请人地址： JPX Tokyo JPX Tokyo
- 专利权人： Kyowa Hakko Kogyo Kabushiki Kaisha,Kitasato Kenkyusho
- 当前专利权人： Kyowa Hakko Kogyo Kabushiki Kaisha,Kitasato Kenkyusho
- 当前专利权人地址： JPX Tokyo JPX Tokyo
- 优先权： JPX53-25041 19780307
- 主分类号： A61K31/35
- IPC分类号： A61K31/35 ; A61P31/04 ; C07D493/08 ; C12P17/18 ; C12R1/465 ; C12P17/06
摘要：
The present invention teaches a new antibiotic nanaomycin E represented by the formula: ##STR1## Nanaomycin E is active against Gram-positive bacteria, Trichophyton and Mycoplasma and may be used as antibacterial and therapeutic agents for humans and animals. Nanaomycin E is also a useful starting material for the preparation of nanaomycin A which latter nanaomycin has the highest activity among the various nanaomycin-type compounds. Nanaomycin E is produced by fermentation of a microorganism belonging to the genus Streptomyces and capable of producing nanaomycin E, especially Streptomyces rosa variant notoensis (FERM-P 2209; ATCC 31135) and recovering the same from the fermented liquor.
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