公开(公告)号：US20250043319A1

公开(公告)日：2025-02-06

申请号：US18918626

申请日：2024-10-17

Applicant: Invizyne Technologies, Inc.

Inventor： John BILLINGSLEY ,  Tyler P. KORMAN ,  Mohammad HAYAT

IPC: C12P7/22 ,  C12N9/10 ,  C12P17/06

Abstract: The present disclosure relates to compositions comprising cyclolavandulyl derivatives of aromatic compounds, such as cannabinoids, flavonoids, and alkaloids, and methods for preparing and using the compositions.

公开(公告)号：US20250011735A1

公开(公告)日：2025-01-09

申请号：US18262922

申请日：2022-01-26

Applicant: CB Therapeutics, Inc.

Inventor： Erin Marie Scott ,  Kirsten Tang ,  Jacob Michael Vogan

IPC: C12N9/10 ,  C12N15/52 ,  C12N15/81 ,  C12P5/00 ,  C12P7/42 ,  C12P17/06

Abstract: Provided is a nucleic acid comprising a recombinant bacterial or archaeal geranyl pyrophosphate synthase (GPPS) gene, codon optimized for production in yeast. Also provided is a yeast cell comprising an expression cassette comprising the above nucleic acid. Additionally provided is a method of producing a terpene or cannabinoid in a yeast, the method comprising incubating the above yeast cell in a manner sufficient to produce the terpene or cannabinoid.

公开(公告)号：US20240409572A1

公开(公告)日：2024-12-12

申请号：US18259761

申请日：2021-12-23

Applicant: SARAWAK BIODIVERSITY COUNCIL

Inventor： Tiong Chia YEO ,  Julian, Cheng Liang VOONG ,  Noreha Binti MAHIDI ,  Mohd Farith bin KOTA ,  Nuraqilah binti OTHMAN ,  Michele MEJIN ,  Nyuk Fong KON ,  Mohammad Farhan Darin bin AZRI ,  Mitchel Constance ak GEORGE

IPC: C07H15/203 ,  A61K31/7034 ,  A61K36/062 ,  C12P17/06 ,  C12R1/77

Abstract: A compound, represented by formula (I): wherein R, R1, R2 and R4 are independently of one another a hydrogen atom or a C1-C6 linear or branched alkyl, or a C1-C6 linear or branched alkenyl, or a C1-C6 linear or branched alkynyl; R3 is a hydrogen atom, OR4 or a C1-C6 linear or branched alkyl, or a C1-C6 linear or branched alkenyl, or a C1-C6 linear or branched alkynyl; and n=4 to 11; its functions and isolation process thereof.

公开(公告)号：US12122994B2

公开(公告)日：2024-10-22

申请号：US18186257

申请日：2023-03-20

Applicant: TEMASEK LIFE SCIENCES LABORATORY LIMITED

Inventor： Lianghui Ji ,  Si Te Ngoh

IPC: C12N1/14 ,  C12P17/06 ,  C12R1/645

CPC classification number: C12N1/14 ,  C12N1/145 ,  C12P17/06 ,  C12N2500/22 ,  C12N2500/24 ,  C12N2500/42 ,  C12R2001/645

Abstract: A culture for the fermentative production of Massoia lactone comprising an Aureobasidium melanogenum species in a culture medium, wherein the Aureobasidium melanogenum species expresses no functional Aureobasidin A synthase gene mRNA when cultured, the culture medium including KH2PO4, Na2HPO4, (NH4)2SO4, MgSO4·7H2O and CaCl2·2H2O; at least two trace elements selected from the group consisting of Fe2+, Cu2+, Zn2+ and MoO42−; urea; and a carbon source selected from the group consisting of glucose, mannose, xylose and mixtures thereof, wherein the culture medium has a pH from 5.5 to 6.5.

公开(公告)号：US20240279694A1

公开(公告)日：2024-08-22

申请号：US18582231

申请日：2024-02-20

Applicant: BIOMEDICAN, INC.

Inventor： Maxim Mikheev ,  Difeng Gao

IPC: C12P17/06 ,  C12N9/00 ,  C12N9/02 ,  C12N9/04 ,  C12N9/10 ,  C12N9/88

CPC classification number: C12P17/06 ,  C12N9/0004 ,  C12N9/0006 ,  C12N9/1029 ,  C12N9/1085 ,  C12N9/88 ,  C12N9/93 ,  C12Y101/01034 ,  C12Y121/03007 ,  C12Y121/03008 ,  C12Y203/0102 ,  C12Y203/01206 ,  C12Y404/01026 ,  C12Y604/01002

Abstract: The present disclosure relates to the production of cannabinoids in yeast. In as aspect there is provided a genetically modified yeast comprising: one or more GPP producing genes and optionally, one or more GPP pathway genes; two or more olivetolic acid producing genes; one or more cannabinoid precursor or cannabinoid producing genes; one or more Hexanoyl-CoA producing genes, and at least 5% dry weight of fatty acids or fats.

公开(公告)号：US12060592B2

公开(公告)日：2024-08-13

申请号：US17089498

申请日：2020-11-04

Applicant: Codexis Inc.

Inventor： Steven J. Collier ,  Ee Ling Teo ,  Joly Sukumaran ,  Robert J. Wilson ,  Junye Xu

IPC: C12N9/10 ,  C07K14/00 ,  C12N15/52 ,  C12P7/62 ,  C12P17/06

CPC classification number: C12P17/06 ,  C07K14/00 ,  C12N9/1025 ,  C12N9/1029 ,  C12N15/52 ,  C12P7/62 ,  C12Y203/01 ,  Y02P20/52

Abstract: Methods for the improved acylation of chemical substrates using LovD acyltransferases, thioesters having acyl groups, and (i) thiol scavengers and/or (ii) precipitating agents are presented. An improved method for the production of simvastatin using (i) activated charcoal as a thiol scavenger and/or (ii) ammonium hydroxide as a precipitating agent is also presented.

公开(公告)号：US20240167066A1

公开(公告)日：2024-05-23

申请号：US18283610

申请日：2022-03-24

Applicant: DAICEL CORPORATION

Inventor： Akira OTANI ,  Hiroaki YAMAMOTO ,  Kazuya MITSUHASHI ,  Takafumi MITACHI ,  Satoru FUKIYA ,  Atsushi YOKOTA

IPC: C12P17/06 ,  C12N1/20 ,  C12N9/06 ,  C12N9/10 ,  C12P7/22 ,  C12P17/12 ,  C12R1/185 ,  C12R1/22 ,  C12R1/225 ,  C12R1/46

CPC classification number: C12P17/06 ,  C12N1/205 ,  C12N9/003 ,  C12N9/1014 ,  C12P7/22 ,  C12P17/12 ,  C12R2001/185 ,  C12R2001/22 ,  C12R2001/225 ,  C12R2001/46 ,  C12Y201/02001

Abstract: An object of the present disclosure is at least to provide a technique for promoting elimination of a methyl group(s) of a methoxy group(s) in causing a microorganism having a demethylation ability of eliminating a methyl group(s) of a methoxy group(s) from a compound with the methoxy group(s) in a side chain(s) to produce a demethylated compound in which a methyl group(s) of a methoxy group(s) has eliminated from a compound with the methoxy group(s) in a side chain(s). The issue is solved by a method for producing a demethylated compound, comprising co-culturing, in a solution containing a compound with a methoxy group(s) in a side chain(s), a microorganism having a demethylation ability of eliminating a methyl group(s) of a methoxy group(s) from a compound with the methoxy group(s) in a side chain(s), and a microorganism having an activity to promote the demethylation, to produce the demethylated compound in which a methyl group(s) of a methoxy group(s) has eliminated from the compound with the methoxy group(s) in the side chain(s).

公开(公告)号：US11981945B2

公开(公告)日：2024-05-14

申请号：US17238312

申请日：2021-04-23

Applicant: C3 Bio-Technologies Limited

Inventor： Vijaykumar Karuppiah ,  Nicole G. H. Leferink ,  Nigel S. Scrutton

IPC: C12P17/06 ,  C12N9/88 ,  C12P7/04

CPC classification number: C12P17/06 ,  C12N9/88 ,  C12P7/04 ,  C12Y402/03025 ,  C12Y402/03026 ,  C12Y402/03108

Abstract: The present invention relates to a process of producing a monoterpene and/or derivatives thereof. The process comprises the steps of: a) providing a host microorganism genetically engineered to express a bacterial monoterpene synthase (mTS); and b) contacting geranyl pyrophosphate (GPP) with said bacterial mTS to produce said monoterpene and/or derivatives thereof. The present invention also relates to a microorganism for use in producing a monoterpene and/or derivatives thereof and a recombinant microor-ganism adapted to conduct the step of converting geranyl pyrophosphate (GPP) into a monoterpene and/or derivatives thereof by ex-pression of a bacterial mTS. It was shown to produce 1,8 cineole using 1,8 cineole synthase and to produce linalool using linalool synthase, both from Streptomyces clavuligerus.

公开(公告)号：US11981938B2

公开(公告)日：2024-05-14

申请号：US16753983

申请日：2018-10-04

Applicant: Eleszto Genetika, Inc.

Inventor： Bela Krisztian Szamecz ,  Szilvia Varszegi ,  Attila Nemeth ,  Lorand Szabo ,  Abhinav Kumar

IPC: C12N9/10 ,  A61K31/352 ,  C12N1/21 ,  C12N15/81 ,  C12P7/42 ,  C12P17/06

CPC classification number: C12N9/1085 ,  A61K31/352 ,  C12N15/81 ,  C12P7/42 ,  C12P17/06

Abstract: Disclosed herein are microorganism and methods that can be used for the synthesis of cannabigerolic acid (CBGA) and cannabinoids. The methods disclosed can be used to produce CBGA, Δ9-tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA), cannabichromenic acid (CBCA), Δ9-tetrahydrocannabinol (THC), cannabidiol (CBD), cannabichromene (CBC). Enzymes useful for the synthesis of CBGA and cannabinoids, include but are not limited to acyl activating enzyme (AAE1), polyketide synthase (PKS), olivetolic acid cyclase (OAC), prenyltransferase (PT), THCA synthase (THCAS), CBDA synthase (CBDAS), CBCA synthase (CBCAS), HMG-Co reductase (HMG1), and/or farnesyl pyrophosphate synthetase (ERG20). The microorganisms can also have one or more genes disrupted, such as gene that that controls beta oxidation of long chain fatty acids.

公开(公告)号：US20240124899A1

公开(公告)日：2024-04-18

申请号：US18458762

申请日：2023-08-30

Applicant: Board of Trustees of Michigan State University

Inventor： Björn Hamberger ,  Sean Johnson ,  Wajid Waheed Bhat

IPC: C12P5/00 ,  C12N9/10 ,  C12N15/82 ,  C12P17/02 ,  C12P17/06

CPC classification number: C12P5/002 ,  C12N9/1022 ,  C12N9/1085 ,  C12N15/8243 ,  C12P17/02 ,  C12P17/06 ,  C12Y202/01007 ,  C12Y205/01029

Abstract: Enzymes and methods are described herein for manufacturing terpenes, including terpenes.