A process for separating indole from a mixture of indole with at least one hydrocarbon or its derivative which comprises the steps of contacting the mixture with a faujasite structured zeolite to selectively adsorb indole on the zeolite and contacting a desorbent A selected from the group consisting of C.sub.2-10 aliphatic or C.sub.7-10 aromatic ether compounds, C.sub.2-10 aliphatic ester compounds and C.sub.3-10 aliphatic ketone compounds with the indole-adsorbed zeolite to separate indole and the process which comprises, in addition, the step of contacting at least one desorbent B of the formula, ##STR1## wherein R.sup.1 is a C.sub.1-3 alkyl group, andR.sup.2 is a hydrogen atom or a C.sub.1-3 alkyl group,with the indole-adsorbed zeolite prior to the contact of the desorbent A with the indole-adsorbed zeolite.