发明授权
- 专利标题： Epoxysuccinic acid derivatives
- 专利标题（中）： 环氧琥珀酸衍生物
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申请号： US880180申请日： 1978-02-22
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公开(公告)号： US4393228A公开(公告)日： 1983-07-12
- 发明人: Jiro Sawada , Kazunori Hanada , Masaharu Tamai , Shigeo Morimoto , Sadafumi Omura
- 申请人： Jiro Sawada , Kazunori Hanada , Masaharu Tamai , Shigeo Morimoto , Sadafumi Omura
- 申请人地址： JPX Tokyo
- 专利权人： Taisho Pharmaceutical Co., Ltd.
- 当前专利权人： Taisho Pharmaceutical Co., Ltd.
- 当前专利权人地址： JPX Tokyo
- 优先权： JPX52-23092 19770303; JPX52-23536 19770304; JPX52-23537 19770304
- 主分类号： C07D303/48
- IPC分类号： C07D303/48 ; C07D407/02 ; C07D407/12 ; C07D411/12
摘要：
The epoxysuccinic acid derivatives of this invention are prepared by esterification of an epoxysuccinic acid or a halide thereof, by partial hydrolysis of an epoxysuccinic acid diester, by amidation of an epoxysuccinic acid monoester, or by hydrolysis of an epoxysuccinic acid amide monoester. These epoxysuccinic acid derivatives have excellent thiol protease inhibitory activity and anti-inflammatory activity without the acceleration of vascular permeability.
公开/授权文献
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