发明授权
- 专利标题: Analgesic 4-hydroxy-3-quinolinecarboxamides
- 专利标题(中): 止痛4-羟基-3-喹啉甲酰胺
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申请号: US262952申请日: 1981-05-12
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公开(公告)号: US4397856A公开(公告)日: 1983-08-09
- 发明人: Andre Allais , Francois Clemence , Roger Deraedt , Odile Lemartret
- 申请人: Andre Allais , Francois Clemence , Roger Deraedt , Odile Lemartret
- 申请人地址: FRX Paris
- 专利权人: Roussel Uclaf
- 当前专利权人: Roussel Uclaf
- 当前专利权人地址: FRX Paris
- 优先权: FRX8011100 19800519
- 主分类号: A61K31/47
- IPC分类号: A61K31/47 ; A61P25/04 ; A61P29/00 ; C07C237/04 ; C07C237/22 ; C07D215/56 ; C07D233/88 ; C07D263/48 ; C07D265/16 ; C07D265/22 ; C07D277/20 ; C07D277/46 ; C07D277/82 ; C07D401/12 ; C07D409/12 ; C07D413/12 ; C07D417/12
摘要:
Novel compounds of the formula ##STR1## wherein X is in the 5,6,7 or 8 position and is selected from the group consisting of hydrogen, halogen, alkyl of 1 to 5 carbon atoms, alkoxy of 1 to 4 carbon atoms, CF.sub.3 O--, CF.sub.3 S-- and CF.sub.3 --, R.sub.1 ' is selected from the group consisting of hydrogen and alkyl of 1 to 4 carbon atoms, R.sub.2 ' is selected from the group consisting of hydrogen or an optionally unsaturated ring able to contain one or more heteroatoms of the group consisting of --S--, --O-- and --N-- optionally substituted with one or more members of the group consisting of (a) halogens, (b) alkyl of 1 to 4 carbon atoms optionally substituted with NH.sub.2, --NHAlK or --N---(AlK).sub.2 and AlK is alkyl of 1 to 3 carbon atoms, (c) phenyl, (d) alkoxy of 1 to 4 carbon atoms, (e) --OH, (f) --CF.sub.3 and (g) --NO.sub.2 or R.sub.1 ' together with the nitrogen atom to which they are attached form an optionally unsaturated ring, the said ring then being connected to the nitrogen atom by a double bond, R.sub.3 is selected from the group consisting of hydrogen, halogen and alkyl of 1 to 4 carbon atoms, R.sub.4 is selected from the group consisting of hydrogen and halogen, R.sub.5 is a halogen with the proviso that R.sub.3, R.sub.4 and R.sub.5 can not all be fluorine and R.sub.6 is selected from the group consisting of hydrogen, alkyl of 1 to 8 carbon atoms and an acyl of an organic carboxylic acid of 2 to 8 carbon atoms and their non-toxic, pharmaceutically acceptable acid addition salts and their salts with non-toxic, pharmaceutically acceptable bases having a remarkable analgesic activity, a very weak anti-inflammatory activity and a good tolerance by the gastrointestinal system and their preparation and their intermediates.
公开/授权文献
- US5451746A Temperature control system for a cooking oven 公开/授权日:1995-09-19
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