发明授权
- 专利标题: 4-Aroylimidazol-2-ones and their use as pharmaceuticals
- 专利标题(中): 4-芳酰基咪唑-2-酮及其作为药物的用途
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申请号: US417805申请日: 1982-09-13
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公开(公告)号: US4405635A公开(公告)日: 1983-09-20
- 发明人: Richard A. Schnettler , Richard C. Dage , Johann M. Grisar
- 申请人: Richard A. Schnettler , Richard C. Dage , Johann M. Grisar
- 申请人地址: OH Cincinnati
- 专利权人: Merrell Dow Pharmaceuticals Inc.
- 当前专利权人: Merrell Dow Pharmaceuticals Inc.
- 当前专利权人地址: OH Cincinnati
- 主分类号: C07D233/70
- IPC分类号: C07D233/70 ; A61K31/415
摘要:
Novel 4-aroylimidazol-2-ones of the following general structure which are useful as antihypertensives, cardiotonics, antithrombotics, bronchodilators and uterospasmolytics ##STR1## wherein Ar is 2-furyl, 2-thienyl or phenyl, the latter of which may optionally be substituted with one or two X groups; X is halogen, hydroxy, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, methylenedioxy, C.sub.1-4 alkylthio, C.sub.1-4 alkylsulfoxide, C.sub.1-4 alkylsulfone, CF.sub.3, --SO.sub.2 N(R.sub.2).sub.2, NR.sub.3 R.sub.4, pyrrolidino, piperidino, morpholino, piperazino or N'-alkyl-piperazino, R is hydrogen, C.sub.1-4 alkyl, C.sub.1-4 alkylcarbonyl or benzyl; each of R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are hydrogen or C.sub.1-4 alkyl; and the pharmaceutically acceptable salts thereof.
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