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公开(公告)号：US4126612A
公开(公告)日：1978-11-21
申请号：US877664
申请日：1978-02-14
IPC分类号： C07D207/22 , C07D211/72 , C07D223/10 , C07D223/12 , C07D225/02
CPC分类号： C07D207/22 , C07D211/72 , C07D223/10 , C07D223/12 , C07D225/02 , Y10S514/822 , Y10S514/866 , Y10S514/869 , Y10S514/884
摘要： Compounds possessing hypoglycemic, hypotensive, anti-inflammatory, anticoagulant and diuretic activity are represented by compounds of the following formula ##STR1## wherein Y is thienyl, cycloalkyl of from 5 to 7 carbon atoms, phenyl or substituted phenyl in which case the substituents on the substituted phenyl are selected from halogen, such as fluorine, chlorine, bromine or iodine, lower alkyl of from 1 to 4 carbon atoms and lower alkoxy of from 1 to 4 carbon atoms; Z is hydrogen or hydroxy; R is hydrogen, lower alkyl of from 1 to 4 carbon atoms, phenyl or benzyl; R.sup.1 is hydrogen, lower alkyl of from 1 to 4 carbon atoms or halogen, such as chlorine, fluorine, bromine or iodine; m is from 3 to 6; and n is from 3 to 11. Pharmaceutical compositions of these compounds and their use are also disclosed.
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公开(公告)号：US4405635A
公开(公告)日：1983-09-20
申请号：US417805
申请日：1982-09-13
IPC分类号： C07D233/70 , A61K31/415
CPC分类号： C07D233/70
摘要： Novel 4-aroylimidazol-2-ones of the following general structure which are useful as antihypertensives, cardiotonics, antithrombotics, bronchodilators and uterospasmolytics ##STR1## wherein Ar is 2-furyl, 2-thienyl or phenyl, the latter of which may optionally be substituted with one or two X groups; X is halogen, hydroxy, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, methylenedioxy, C.sub.1-4 alkylthio, C.sub.1-4 alkylsulfoxide, C.sub.1-4 alkylsulfone, CF.sub.3, --SO.sub.2 N(R.sub.2).sub.2, NR.sub.3 R.sub.4, pyrrolidino, piperidino, morpholino, piperazino or N'-alkyl-piperazino, R is hydrogen, C.sub.1-4 alkyl, C.sub.1-4 alkylcarbonyl or benzyl; each of R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are hydrogen or C.sub.1-4 alkyl; and the pharmaceutically acceptable salts thereof.
摘要翻译： 可用作抗高血压药，强心剂，抗血栓药物，支气管扩张剂和子宫解脂素的以下通用结构的新型4-芳酰基咪唑-2-酮其中Ar为2-呋喃基，2-噻吩基或苯基，后者可任选地被取代 与一个或两个X组; X是卤素，羟基，C 1-4烷基，C 1-4烷氧基，亚甲二氧基，C 1-4烷硫基，C 1-4烷基亚砜，C 1-4烷基砜，CF 3，-SO 2 N（R 2）2，NR 3 R 4，吡咯烷子基，哌啶子基，吗啉代， 哌嗪基或N'-烷基 - 哌嗪子基，R是氢，C 1-4烷基，C 1-4烷基羰基或苄基; R 1，R 2，R 3和R 4各自为氢或C 1-4烷基; 及其药学上可接受的盐。
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公开(公告)号：US4126611A
公开(公告)日：1978-11-21
申请号：US877663
申请日：1978-02-14
IPC分类号： C07D207/22 , C07D211/72 , C07D223/10 , C07D223/12 , C07D225/02
CPC分类号： C07D207/22 , C07D211/72 , C07D223/10 , C07D223/12 , C07D225/02 , Y10S514/822 , Y10S514/866 , Y10S514/869 , Y10S514/884
摘要： Compounds possessing hypoglycemic, hypotensive, antiinflammatory, anticoagulant and diuretic activity are represented by compounds of the following formula ##STR1## wherein Y is thienyl, cycloalkyl of from 5 to 7 carbon atoms, phenyl or substituted phenyl in which case the substituents on the substituted phenyl are selected from halogen, such as fluorine, chlorine, bromine or iodine, lower alkyl of from 1 to 4 carbon atoms and lower alkoxy of from 1 to 4 carbon atoms; Z is hydrogen or hydroxy; R is hydrogen, lower alkyl of from 1 to 4 carbon atoms, phenyl or benzyl; R.sup.1 is hydrogen, lower alkyl of from 1 to 4 carbon atoms or halogen, such as chlorine, fluorine, bromine or iodine; m is from 3 to 6; and n is from 3 to 11. Pharmaceutical compositions of these compounds and their use are also disclosed.
摘要翻译： 具有降血糖，降血压，抗炎，抗凝血和利尿活性的化合物由下式的化合物表示，其中Y是噻吩基，5-7个碳原子的环烷基，苯基或取代的苯基，在这种情况下，取代基 取代的苯基选自卤素如氟，氯，溴或碘，1至4个碳原子的低级烷基和1至4个碳原子的低级烷氧基; Z是氢或羟基; R为氢，1至4个碳原子的低级烷基，苯基或苄基; R1是氢，1至4个碳原子的低级烷基或卤素，如氯，氟，溴或碘; m为3〜6; 并且n为3至11.这些化合物的药物组合物及其用途也被公开。
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公开(公告)号：US4153235A
公开(公告)日：1979-05-08
申请号：US877653
申请日：1978-02-14
IPC分类号： C07D207/22 , C07D211/72 , C07D223/10 , C07D223/12 , C07D225/02 , C07D223/04
CPC分类号： C07D207/22 , C07D211/72 , C07D223/10 , C07D223/12 , C07D225/02 , Y10S514/822 , Y10S514/866 , Y10S514/869 , Y10S514/884
摘要： Compounds possessing hypoglycemic, hypotensive, anti-inflammatory, anticoagulant and diuretic acitivity are represented by compounds of the following formula ##STR1## wherein Y is thienyl, cycloalkyl of from 5 to 7 carbon atoms, phenyl or substituted phenyl in which case the substituents on the substituted phenyl are selected from halogen, such as fluorine, chlorine, bromine or iodine, lower alkyl of from 1 to 4 carbon atoms and lower alkoxy of from 1 to 4 carbon atoms; Z is hydrogen or hydroxy; R is hydrogen, lower alkyl of from 1 to 4 carbon atoms, phenyl or benzyl; R.sup.1 is hydrogen, lower alkyl of from 1 to 4 carbon atoms or halogen, such as chlorine, fluorine, bromine or iodine; m is from 3 to 6; and n is from 3 to 11. Pharmaceutical compositions of these compounds and their use are also disclosed.
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公开(公告)号：US4126621A
公开(公告)日：1978-11-21
申请号：US877652
申请日：1978-02-14
IPC分类号： C07D207/22 , C07D211/72 , C07D223/10 , C07D223/12 , C07D225/02 , A61K31/40 , A61K31/445 , A61K31/55 , C07D409/08
CPC分类号： C07D207/22 , C07D211/72 , C07D223/10 , C07D223/12 , C07D225/02 , Y10S514/822 , Y10S514/866 , Y10S514/869 , Y10S514/884
摘要： Compounds possessing hypoglycemic, hypotensive, antiinflammatory, anticoagulant and diuretic activity are represented by compounds of the following formula ##STR1## wherein Y is thienyl, cycloalkyl of from 5 to 7 carbon atoms, phenyl or substituted phenyl in which case the substituents on the substituted phenyl are selected from halogen, such as fluorine, chlorine, bromine or iodine, lower alkyl of from 1 to 4 carbon atoms and lower alkoxy of from 1 to 4 carbon atoms; Z is hydrogen or hydroxy; R is hydrogen, lower alkyl of from 1 to 4 carbon atoms, phenyl or benzyl; R.sup.1 is hydrogen, lower alkyl of from 1 to 4 carbon atoms or halogen, such as chlorine, fluorine, bromine or iodine; m is from 3 to 6; and n is from 3 to 11. Pharmaceutical compositions of these compounds and their use are also disclosed.
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公开(公告)号：US4126613A
公开(公告)日：1978-11-21
申请号：US386995
申请日：1973-08-09
IPC分类号： C07C17/26 , C07C45/28 , C07C45/68 , C07D211/72 , C07D211/76 , C07D333/20 , C07D207/22 , C07D223/00 , C07D225/00
CPC分类号： C07C17/263 , C07C17/2632 , C07C45/28 , C07C45/68 , C07D211/72 , C07D211/76 , C07D333/20 , Y10S514/822 , Y10S514/866 , Y10S514/869
摘要： Compounds possessing hypoglycemic, hypotensive, anti-inflammatory, anticoagulant and diuretic activity are represented by compounds of the following formula ##STR1## where Y is thienyl, cycloalkyl of from 5 to 7 carbon atoms, phenyl or substituted phenyl in which case the substituents on the substituted phenyl are selected from halogen, such as fluorine, chlorine, bromine or iodine, lower alkyl of from 1 to 4 carbon atoms and lower alkoxy of from 1 to 4 carbon atoms; Z is hydrogen or hydroxy; R is hydrogen, lower alkyl of from 1 to 4 carbon atoms, phenyl or benzyl; R.sup.1 is hydrogen, lower alkyl of from 1 to 4 carbon atoms or halogen, such as chlorine, fluorine, bromine or iodine; m is from 3 to 6; and n is from 3 to 11. Pharmaceutical compositions of these compounds and their use are also disclosed.
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公开(公告)号：US3983248A
公开(公告)日：1976-09-28
申请号：US169861
申请日：1971-08-06
IPC分类号： A61K31/18 , C07C311/15
CPC分类号： A61K31/18 , C07C311/15
摘要： Compounds useful as antiviral agents are those of the formula ##SPC1##Wherein each R.sup.1 is hydrogen or methyl; each n is an integer of 2 to 4; each of R.sup.2 and R.sup.3 is alkyl of 3 to 5 carbon atoms or alkenyl of 3 to 5 carbon atoms; or a pharmaceutically acceptable acid addition salt of said base. Pharmaceutical compositions are formed from these compounds with pharmaceutically acceptable carriers.
摘要翻译： 可用作抗病毒剂的化合物是下式的化合物，其中每个R 1是氢或甲基; 每个n为2至4的整数; R2和R3各自为3至5个碳原子的烷基或3至5个碳原子的烯基; 或所述碱的药学上可接受的酸加成盐。 药物组合物由这些化合物与药学上可接受的载体形成。
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