发明授权
US4408059A Spiroketals useful as intermediates in the synthesis of milbemycin and
avermectin macrolides
失效
螺旋酮可用作合成米尔倍霉素和阿维菌素大环内酯的中间体
- 专利标题： Spiroketals useful as intermediates in the synthesis of milbemycin and avermectin macrolides
- 专利标题（中）： 螺旋酮可用作合成米尔倍霉素和阿维菌素大环内酯的中间体
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申请号： US327641申请日： 1981-12-04
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公开(公告)号： US4408059A公开(公告)日： 1983-10-04
- 发明人: Amos B. Smith, III , Steven R. Schow
- 申请人： Amos B. Smith, III , Steven R. Schow
- 申请人地址： CT Norwalk
- 专利权人： University Patents, Inc.
- 当前专利权人： University Patents, Inc.
- 当前专利权人地址： CT Norwalk
- 主分类号： C07H19/01
- IPC分类号： C07H19/01 ; C07D309/06 ; C07C65/00 ; C07D493/22 ; C07H17/08
摘要：
Milbemycin and avermectin macrolides are synthesized by the cyclized linking of separately synthesized northern and southern hemisphere intermediates. The northern hemisphere intermediate is a spiroketal alkenyl aldehyde, and the southern hemisphere intermediate is an aryl alkenyl phosphine oxide anion.
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