发明授权
US4481207A 1-Phenethyl-alpha-phenyl-piperidine-3-propanenitriles and their
pharmaceutical uses
失效
1-苯乙基-α-苯基 - 哌啶-3-丙腈及其药物用途
- 专利标题： 1-Phenethyl-alpha-phenyl-piperidine-3-propanenitriles and their pharmaceutical uses
- 专利标题（中）： 1-苯乙基-α-苯基 - 哌啶-3-丙腈及其药物用途
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申请号： US523349申请日： 1983-08-15
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公开(公告)号： US4481207A公开(公告)日： 1984-11-06
- 发明人: Philippe Manoury , Jean Binet , Gerard DeFosse
- 申请人： Philippe Manoury , Jean Binet , Gerard DeFosse
- 申请人地址： FRX Paris
- 专利权人： Synthelabo
- 当前专利权人： Synthelabo
- 当前专利权人地址： FRX Paris
- 优先权： FRX8214154 19820816
- 主分类号： A61K31/443
- IPC分类号： A61K31/443 ; A61K31/445 ; A61K31/451 ; A61P3/00 ; A61P3/14 ; A61P9/08 ; A61P9/12 ; C07C67/00 ; C07C253/00 ; C07C255/37 ; C07D211/18 ; C07D211/22 ; C07D211/30 ; C07D211/34 ; C07D211/60 ; C07D317/00 ; C07D317/64 ; C07D319/00 ; C07D405/06
摘要：
Compounds of the formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 each represent a hydrogen atom, a halogen atom, a (C.sub.1-4)alkoxy radical, a (C.sub.1-4)alkylthio radical, a halogeno(C.sub.1-4)alkyl radical, a (C.sub.1-4)alkyl radical or a cycloalkyl-alkoxy-alkoxy radical or two of the adjacent R symbols together form a methylenedioxy or ethylenedioxy radical, R.sub.6 represents a hydrogen atom, a (C.sub.1-4)alkyl radical, a (C.sub.3-6)cycloalkyl radical or a (C.sub.3-6)cycloalkyl-(C.sub.1-4)alkyl radical, and R.sub.7, R.sub.8 and R.sub.9 each represent a hydrogen atom or a methoxy radical, are new compounds possessing pharmacological properties; they are useful as calcium antagonists and as antihypertensives.
公开/授权文献
- US5039776A Production of particulate polyimide polymers 公开/授权日：1991-08-13